The Role of the Vagus Nerve in Tumor-to-Brain Communication in Lung Cancer Patients - Full Text View

The Role of the Vagus Nerve in Tumor-to-Brain Communication in Lung Cancer Patients

This study is currently recruiting participants.
Verified by Rambam Health Care Campus, November 2006

Sponsored by:	Rambam Health Care Campus
Information provided by:	Rambam Health Care Campus
ClinicalTrials.gov Identifier:	NCT00397124

Purpose

the aim of this study is to measure brain metabolism in patients with lung cancer.FDG uptake in the brain in patients with malignant tumors will be compared to the amount of tracer activity found in patients who have benign pulmonary process. if differences between the brain uptake of FDG in the two groups will be found, further assessment will be performed in order to evaluate if such differences could be attributed and specifically localized to the brain regions innervated by the vagus

Condition	Intervention
Lung Cancer	Device: PET/CT imaging

MedlinePlus related topics:

Cancer Lung Cancer

U.S. FDA Resources

Study Type:	Interventional
Study Design:	Randomized, Open Label, Active Control, Parallel Assignment

Official Title:	Does the Vagus Nerve Play a Role in Tumor-to-Brain Communication? a Preliminary Study in Patients With Newly Diagnosed Lung Cancer

Further study details as provided by Rambam Health Care Campus:

Primary Outcome Measures:

the impact of the imaging modality on patients management

Secondary Outcome Measures:

the impact of the imaging modality on patients management

Estimated Enrollment:	40
Study Start Date:	April 2002

Eligibility

Ages Eligible for Study:	35 Years to 70 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

patients with SPN referred for routine whole body FDG-PET imaging
patients with NSCLC and patients with no evidence of lung cancer on further follow up

Exclusion Criteria:

patients with a clinical history of vagotomy, abdominal surgery. brain tumor, brain trauma or CVA. or those with a systemic inflammatory disease

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00397124

Contacts


Contact: Alex Frenkel, Ph.D	972-4-8543009	a_frenkel@rambam.health.gov.il

Locations


Israel
	Rambam Medical Center	Recruiting
	Haifa, Israel
	Contact: Alex Frenkel, Ph.D 972-4-8543009 a_frenkel@rambam.health.gov.il

Sponsors and Collaborators

Rambam Health Care Campus

Investigators


Principal Investigator:	Ora Israel, MD	Rambam Health Care Campus

More Information

Study ID Numbers:	vagusCTIL
First Received:	November 7, 2006
Last Updated:	November 7, 2006
ClinicalTrials.gov Identifier:	NCT00397124
Health Authority:	Israel: Israeli Health Ministry Pharmaceutical Administration

Study placed in the following topic categories:

Thoracic Neoplasms

Respiratory Tract Diseases

Lung Neoplasms

Lung Diseases

Additional relevant MeSH terms:

Respiratory Tract Neoplasms

Neoplasms

Neoplasms by Site

ClinicalTrials.gov processed this record on October 29, 2008