|
|
|
|
|
|
Sponsors and Collaborators: |
Emory University American Federation for Aging Research |
Information provided by: | Emory University |
ClinicalTrials.gov Identifier: | NCT00585949 |
Coronary artery disease is a leading cause of morbidity and mortality in our society. It is initiated by the dysfunction of the lining of coronary arteries. There are several repair mechanisms that are now thought to involve circulating endothelial progenitor cells that are mobilized from the bone marrow and home to sites of endothelial injury. We hypothesize that aging is associated with reduced vascular injury induced endothelial progenitor cell activity, resulting in impaired vascular repair and increased coronary heart disease events. 96 patient with stable coronary artery disease will be enrolled in this study. They will undergo either angiography alone or angiography and angioplasty. Their venous blood will be collected immediately prior to the procedure and 20-24 hours after their procedure. The number of endothelial progenitor cells will be assessed based on their ability to form colonies and also to migrate under the influence of certain growth factors. These values will be compared between both samples. All the patients will also be contacted at 6 months, 2 and 5 years after their participation in the study and the clinical outcomes of their coronary artery disease will be correlated with the number of those aforementioned cells.
Condition | Intervention |
Coronary Artery Disease |
Procedure: Percutaneous Coronary Angioplasty |
MedlinePlus related topics: | Angioplasty Coronary Artery Disease |
Study Type: | Observational |
Study Design: | Case Control, Prospective |
Official Title: | "The Effects of Age on Endothelial Progenitor Cell Mobilization in Humans" |
Estimated Enrollment: | 96 |
Study Start Date: | July 2006 |
Estimated Study Completion Date: | July 2009 |
Estimated Primary Completion Date: | July 2009 (Final data collection date for primary outcome measure) |
Groups/Cohorts | Assigned Interventions |
Angio
Patients undergoing angiography without angioplasty
|
Procedure: Percutaneous Coronary Angioplasty
This is a procedure by which the blood vessels of the heart are imaged with an insertion of a catheter in the groin and blocked arteries are opened.
|
Pci
Patients undergoing angioplasty
|
Procedure: Percutaneous Coronary Angioplasty
This is a procedure by which the blood vessels of the heart are imaged with an insertion of a catheter in the groin and blocked arteries are opened.
|
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Sampling Method: | Non-Probability Sample |
Patients
Inclusion Criteria:
Exclusion Criteria:
Contact: Kreton Mavromatis, MD | 404-329-2207 | kmavro@emory.edu |
Contact: Nima Ghasemzadeh, MD | 404-321-6111 ext 7917 | nghase2@emory.edu |
United States, Georgia | |||||
Atlanta VA Medical Center | Recruiting | ||||
Atlanta, Georgia, United States, 30033 | |||||
Contact: Kreton Mavromatis, MD 404-329-2207 Kmavro@emory.edu | |||||
Contact: Nima Ghasemzadeh, MD 404-321-6111 ext 7917 nghase2@emory.edu | |||||
Principal Investigator: Kreton Mavromatis, MD | |||||
Emory University Hospital | Recruiting | ||||
Atlanta, Georgia, United States, 30322 | |||||
Contact: Arshed A Quyyumi, MD 404-727-3655 aquyyum@emory.edu |
Emory University |
American Federation for Aging Research |
Principal Investigator: | Kreton Mavromatis, MD | Emory University |
Responsible Party: | Emory University ( Kreton Mavromatis ) |
Study ID Numbers: | 289-2006 |
First Received: | December 21, 2007 |
Last Updated: | December 21, 2007 |
ClinicalTrials.gov Identifier: | NCT00585949 |
Health Authority: | United States: Institutional Review Board |
|
|
|