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Sponsored by: |
Chinese University of Hong Kong |
Information provided by: | Chinese University of Hong Kong |
ClinicalTrials.gov Identifier: | NCT00164840 |
Maintenance treatment with proton pump inhibitor (PPI) is the most widely recommended modality of treatment for long-term management of gastroesophageal reflux disease (GERD). Yet in clinical practice treatment is commonly given in short courses on as required basis during symptom flare up, particularly for patients with mild to moderate GERD.
On-demand therapy also has the potential advantage that patient does not need to take regular medications, thereby improving the quality of life. However, whether on-demand PPI therapy achieves similar efficacy of symptom control is uncertain.
The aim of this study is to compare the efficacy and quality of life of on-demand and maintenance PPI regimens in long-term management of non-erosive GERD patients. WE hypothesize that on-demand PPI treatment is as effective as maintenance PPI.
Condition | Intervention | Phase |
Gastroesophageal Reflux Disease |
Drug: Esomeprazole |
Phase III |
MedlinePlus related topics: | GERD |
Drug Information available for: | Esomeprazole magnesium Esomeprazole Sodium Omeprazole Omeprazole magnesium |
Study Type: | Interventional |
Study Design: | Treatment, Randomized, Double-Blind, Placebo Control, Parallel Assignment |
Official Title: | Symptomatic Gastroesophageal Reflux Disease: Double Blind Randomized Controlled Study of on-Demand Therapy Versus Maintenance Therapy |
Ages Eligible for Study: | 18 Years to 80 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Study ID Numbers: | OG Study |
First Received: | September 9, 2005 |
Last Updated: | March 25, 2008 |
ClinicalTrials.gov Identifier: | NCT00164840 |
Health Authority: | Hong Kong: Department of Health |
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