Atopic Dermatitis-Like Skin Disease in Pediatric Heart Transplant Patients - Full Text View

Purpose

The skin disease found in pediatric heart transplant patients represents an atopic dermatitis-like rash that is refractory to systemic immunomodulation.

Condition	Intervention	Phase
Dermatitis	Procedure: Skin Biopsy	Phase III

MedlinePlus related topics:

Heart Transplantation Skin Conditions

U.S. FDA Resources

Study Type:	Observational
Study Design:	Cohort, Cross-Sectional

Official Title:	Atopic Dermatitis-Like Skin Disease in Pediatric Heart Transplant Patients

Further study details as provided by University of Minnesota:

Biospecimen Retention: Samples With DNA

Biospecimen Description:

Tissue

Estimated Enrollment:	30
Study Start Date:	November 2002
Estimated Study Completion Date:	November 2010

Intervention Details:

Skin biopsy.

Detailed Description:

We want to determine whether pediatric heart transplant patients with an atopic dermatitis-like rash report a personal and/or family history of atopy (asthma, allergies and atopic dermatitis). In addition comparisons will be made between the presence of atopy between patients with and without the skin rash. Comparisons will be made of systemic immunosuppressive therapies between patients with and without the atopic dermatitis-like rash. Determination will be made as to whether histologic characterization of a skin biopsy specimen is consistent with AD. Thorough evaluations will be made of patients in the clinic with this rash and the presence of bacterial superinfection will be ruled out.

Eligibility

Ages Eligible for Study:	up to 16 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No
Sampling Method:	Non-Probability Sample

Study Population

Patients with a heart transplant and atopic dermatitis like skin.

Criteria

Inclusion Criteria:

Patients must have had a heart transplant.
Patients must be less than 16 years of age.

Exclusion Criteria:

Patients who have not had a heart transplant.
Patients who are greater than 16 years of age.

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00176956

Contacts


Contact: Maria Hordinsky, MD	612-625-1493	hordi001@umn.edu

Locations


United States, Minnesota
	University of Minnesota	Recruiting
	Minneapolis, Minnesota, United States, 55455
	Contact: Maria Hordinsky, MD 612-625-1493 hordi001@umn.edu
	Principal Investigator: Maria Hordinsky, MD

Sponsors and Collaborators

Hordinsky, Maria K., MD

Investigators


Principal Investigator:	Maria Hordinsky, MD	University of Minnesota

More Information

Responsible Party:	University of Minnesota ( Maria Hordinsky, MD )
Study ID Numbers:	0110M09983
First Received:	September 12, 2005
Last Updated:	April 25, 2008
ClinicalTrials.gov Identifier:	NCT00176956
Health Authority:	United States: Institutional Review Board

Keywords provided by University of Minnesota:

Post Pediatric Heart Transplant

Study placed in the following topic categories:

Hypersensitivity

Dermatitis, Atopic

Genetic Diseases, Inborn

Skin Diseases

Hypersensitivity, Immediate

Skin Diseases, Eczematous

Skin Diseases, Genetic

Dermatitis

Additional relevant MeSH terms:

Immune System Diseases

ClinicalTrials.gov processed this record on October 23, 2008

Sponsored by:	Hordinsky, Maria K., MD
Information provided by:	University of Minnesota
ClinicalTrials.gov Identifier:	NCT00176956