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Sponsored by: |
HaEmek Medical Center, Israel |
Information provided by: | HaEmek Medical Center, Israel |
ClinicalTrials.gov Identifier: | NCT00675142 |
The timing of IUI following ovulation induction has been the subject of many studies and a consensus has developed that a single insemination approximately thirty-six hours after ovulation induction is sufficien. The introduction of GnRH antagonists preventing a premature LH surge and early ovulation has added a new dimension to fertility treatment. It allows greater accuracy in predicting the timing of ovulation and has been shown to be at least as effective, if not more effective, as ovarian stimulation without antagonists. We hypothesize that by utilizing GnRH antagonists we can increase pregnancy rates during IUI by timing the IUI as close as possible to the moment of ovulation guaranteeing the highest and freshest concentration of motile spermatozoa in the fallopian tube at the time the oocyte is released from the ovary. We therefore propose a randomized open three arm prospective trial utilizing superovulation with GnRH antagonists whereby the IUI is timed to take place 36, 42 or 48 hours after ovulation induction.
Condition | Intervention |
Infertility |
Procedure: Intrauterine Insemination |
MedlinePlus related topics: | Infertility |
Drug Information available for: | Gonadorelin Gonadorelin hydrochloride LH-RH |
Study Type: | Interventional |
Study Design: | Treatment, Randomized, Open Label, Parallel Assignment, Efficacy Study |
Official Title: | A Randomized Open Three Arm Prospective Trial To Determine The Optimal Timing for Intrauterine Insemination After Superovulation With Recombinant Gonadotropins Utilizing GnRH Antagonists |
Estimated Enrollment: | 100 |
Arms | Assigned Interventions |
1: Experimental
IUI 36 hours after ovulation induction
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Procedure: Intrauterine Insemination
Changing the time span between ovulation induction and IUI during fertility treatment.
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2: Experimental
IUI 42 hours after ovulation induction
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Procedure: Intrauterine Insemination
Changing the time span between ovulation induction and IUI during fertility treatment.
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3: Experimental
IUI 48 hours after ovulation induction
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Procedure: Intrauterine Insemination
Changing the time span between ovulation induction and IUI during fertility treatment.
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Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Female |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
Contact: Amir Weiss, MD | 972-649-5565 | weiss_am@clalit.org.il |
Israel | |||||
HaEmek Medical Center | |||||
Afula, Israel, 18101 |
HaEmek Medical Center, Israel |
Principal Investigator: | Amir Weiss, MD | HaEmek Medical Center |
Responsible Party: | HaEmek Medical Center ( Amir Weiss MD ) |
Study ID Numbers: | 5-08EMC.CTIL |
First Received: | May 7, 2008 |
Last Updated: | May 7, 2008 |
ClinicalTrials.gov Identifier: | NCT00675142 |
Health Authority: | Israel: Ministry of Health |
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