Additional Glucose Lowering and Anti-Inflammatory Effects by Acarbose and Alcohol in Subjects With Impaired Glucose Tolerance or Mild Type 2 Diabetes - Full Text View

Additional Glucose Lowering and Anti-Inflammatory Effects by Acarbose and Alcohol in Subjects With Impaired Glucose Tolerance or Mild Type 2 Diabetes

This study is currently recruiting participants.
Verified by Taichung Veterans General Hospital, January 2007

Sponsors and Collaborators:	Taichung Veterans General Hospital Tri-Service General Hospital
Information provided by:	Taichung Veterans General Hospital
ClinicalTrials.gov Identifier:	NCT00417950

Purpose

To understand if acarbose, an alpha-glucosidase inhibitor usually for treating diabetes, will further lower post meal glucose and inflammatory state when taking together with moderate amount of alcohol during meal tolerance test in subjects with impaired glucose tolerance or mild diabetes.

Condition	Intervention
Diabetes Mellitus Impaired Glucose Tolerance	Drug: Acarbose

MedlinePlus related topics:

Diabetes Stress

Drug Information available for:

Dextrose Ethanol Acarbose

U.S. FDA Resources

Study Type:	Interventional
Study Design:	Treatment, Randomized, Open Label, Placebo Control, Single Group Assignment, Efficacy Study

Further study details as provided by Taichung Veterans General Hospital:

Primary Outcome Measures:

Postprandial hyperglycemia

Secondary Outcome Measures:

Postprandial inflammatory responses
Postprandial oxidative stress

Estimated Enrollment:	30
Study Start Date:	January 2007

Eligibility

Ages Eligible for Study:	25 Years to 75 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

Subjects with mild diabetes without prior medications or impaired glucose tolerance

Exclusion Criteria:

Pregnancy
Recent major cardiac, renal and hepatic disease
Intolerance to alcohol
Allergy to acarbose treatment

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00417950

Contacts


Contact: I Te Lee, MD, MS	886-4-23592525 ext 3065	itlee@vghtc.gov.tw

Locations


Taiwan
	Taichung Veterans General Hospital	Recruiting
	Taichung, Taiwan
	Contact: Wayne H Sheu, MD, PhD 886-4-23592525 ext 3068 whhsheu@vghtc.gov.tw
	Principal Investigator: Wayne H Sheu, MD, PhD
	Sub-Investigator: I Te Lee, MD, MS

Sponsors and Collaborators

Taichung Veterans General Hospital

Tri-Service General Hospital

Investigators


Principal Investigator:	Wayne H Sheu, MD, PhD	Taichung Veterans General Hospital

More Information

Study ID Numbers:	950801/C06138
First Received:	January 1, 2007
Last Updated:	January 3, 2007
ClinicalTrials.gov Identifier:	NCT00417950
Health Authority:	Taiwan: Department of Health

Keywords provided by Taichung Veterans General Hospital:

diabetes

acarbose

alcohol

inflammation

oxidative stress

Mild diabetes mellitus

Study placed in the following topic categories:

Metabolic Diseases

Glucose Intolerance

Diabetes Mellitus

Stress

Endocrine System Diseases

Inflammation

Acarbose

Hyperglycemia

Diabetes Mellitus, Type 2

Endocrinopathy

Glucose Metabolism Disorders

Metabolic disorder

Ethanol

Additional relevant MeSH terms:

Hypoglycemic Agents

Molecular Mechanisms of Pharmacological Action

Physiological Effects of Drugs

Enzyme Inhibitors

Pharmacologic Actions

ClinicalTrials.gov processed this record on October 22, 2008