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Evaluating the Relationship Among Diet, Body Mass Index, and Childhood Asthma

This study is ongoing, but not recruiting participants.

Sponsored by: National Heart, Lung, and Blood Institute (NHLBI)
Information provided by: National Heart, Lung, and Blood Institute (NHLBI)
ClinicalTrials.gov Identifier: NCT00454415
  Purpose

Asthma is a common illness among children in the United States. While there are many known causes of asthma, including tobacco smoke, pollen, dust, or other allergens, the exact cause of asthma in some individuals remains unknown. This study will examine the role that specific dietary factors and body mass index (BMI) play in the development of childhood asthma.


Condition
Asthma

MedlinePlus related topics:   Asthma   

U.S. FDA Resources

Study Type:   Observational
Study Design:   Cohort, Prospective
Official Title:   Prospective Study of Dietary Factors, BMI, and Risk of Asthma in Children

Further study details as provided by National Heart, Lung, and Blood Institute (NHLBI):

Biospecimen Retention:   None Retained

Biospecimen Description:

Enrollment:   16000
Study Start Date:   January 2007
Estimated Study Completion Date:   December 2008

Detailed Description:

Asthma prevalence has steadily increased in the United States since the early 1980s, but the exact cause of this increase remains unknown. It is estimated that at least 8% of Americans have asthma. Although anti-inflammatory medications have proven effective for decreasing asthma exacerbations, there are few treatment options available to prevent the initial onset of the disease. Dietary factors and BMI may play a role in the development of asthma. Specifically, individuals who eat foods containing antioxidants (e.g., vitamin C, vitamin E, and carotenoids), n-3 polyunsaturated fatty acids (e.g., fish oils), and vitamin D may have a decreased risk of developing asthma, while individuals with higher BMI ratios may have an increased asthma risk. The purpose of this study is to evaluate the relationship among dietary factors, BMI, and the incidence of asthma among children.

This study will enroll children participating in the Growing Up Today study and children of nurses who are participating in the Nurses Health Study II. Researchers will analyze participants' previously completed questionnaires on dietary intake, physical activity, height, weight, and the presence of physician-diagnosed asthma. All participants with physician-diagnosed asthma will receive an additional asthma questionnaire. A small portion of these participants will also have their medical records reviewed by study researchers, and mothers of these children will be asked to complete a questionnaire. Additionally, a questionnaire will be sent to and completed by children who do not have asthma and their mothers.

  Eligibility
Ages Eligible for Study:   9 Years to 14 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample

Study Population

U.S. children


Criteria

Inclusion Criteria:

  • Children of women in the Nurses Health Study II (NHS2)
  • Participated in the Growing Up Today study

Exclusion Criteria:

  • None
  Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00454415

Locations
United States, Massachusetts
Channing Laboratory, Brigham and Women's Hospital    
      Boston, Massachusetts, United States, 02115

Sponsors and Collaborators

Investigators
Principal Investigator:     Carlos A. Camargo, MD, DrPH     Channing Laboratory, Brigham and Women's Hospital    
  More Information


Responsible Party:   Brigham & Women's Hospital ( Carlos A. Camargo / PI )
Study ID Numbers:   1376, R01 HL084401-01A1
First Received:   March 28, 2007
Last Updated:   December 27, 2007
ClinicalTrials.gov Identifier:   NCT00454415
Health Authority:   United States: Federal Government

Keywords provided by National Heart, Lung, and Blood Institute (NHLBI):
Diet  
Body Mass Index  
BMI  

Study placed in the following topic categories:
Hypersensitivity
Lung Diseases, Obstructive
Respiratory Tract Diseases
Lung Diseases
Hypersensitivity, Immediate
Asthma
Respiratory Hypersensitivity

Additional relevant MeSH terms:
Immune System Diseases
Bronchial Diseases

ClinicalTrials.gov processed this record on October 22, 2008




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