Chronic Gastrointestinal Sequelae of an Acute Outbreak of Bacterial Gastroenteritis in Walkerton Ontario - Full Text View

Purpose

Acute Bacterial dysentery leads to chronic symptoms of disturbed bowel habit in a minority of individuals. This condition known as post infectious IBS (PI-IBS) remains poorly understood. This could allow material in the bowel to reach deeper tissues of the bowel wall leading to inflammation and changes in muscle and nerve function. This is also early evidence that genetic programming of people with PI-IBS prevents them from turning off inflammation once it begins. Literature suggests that IBS may develop at greater rates in individuals with pro-inflammatory genotype and that these individuals may be at increased risk of inflammatory bowel diseases(IBD)

Condition

Participants Must Be Residents of Walkerton, Ontario Region at the Time of Outbreak

U.S. FDA Resources

Study Type:	Observational
Study Design:	Natural History, Longitudinal, Defined Population, Retrospective/Prospective Study

Further study details as provided by Hamilton Health Sciences:

Study Start Date:	January 2002
Estimated Study Completion Date:	August 2005

Detailed Description:

This research will study chronic gastrointestinal problems in the residents of Walkerton, Onatrio region. Determine whether acute bacterial infection is a risk factor for development of inflammatory bowel disease using the population of Walkerton as a cohort. We hypothesize that exposure to bacterial infection leads to development of post infectious irritable bowel syndrome which is associated with an increase in intestinal permeability and immune activation with low grade intestinal inflammation and that this sequence of events will trigger inflammatory bowel disease in genetically susceptible individuals

Eligibility

Ages Eligible for Study:	16 Years and older
Genders Eligible for Study:	Both

Criteria

Inclusion Criteria:

Participants must be residents of the Walkerton, Ontario region at the time of Outbreak who consented to the study

Exclusion Criteria:

Non residents of Walkerton Ontario at the time of outbreak

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00235326

Contacts


Contact: John K Marshall, MD, MSC	9055222100 ext 76782	marshllj@mcmaster.ca

Locations


Canada, Ontario
	Walkerton	Recruiting
	Walkerton, Ontario, Canada, N0G 2V0
	Contact: John K Marshall, MD, MSc 9055222100 ext 76782 marshllj@mcmaster.ca
	Principal Investigator: John K Marshall, MD, MSc

Sponsors and Collaborators

Hamilton Health Sciences

Investigators


Principal Investigator:	John k Marshall, MD, MSc	Hamilton Health Sciences

More Information

Study ID Numbers:	02-026; 05-346
First Received:	October 6, 2005
Last Updated:	October 6, 2005
ClinicalTrials.gov Identifier:	NCT00235326
Health Authority:	Canada: Health Canada

Study placed in the following topic categories:

Gastroenteritis

ClinicalTrials.gov processed this record on October 17, 2008

Sponsored by:	Hamilton Health Sciences
Information provided by:	Hamilton Health Sciences
ClinicalTrials.gov Identifier:	NCT00235326