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| Sponsored by: |
National Heart, Lung, and Blood Institute (NHLBI) |
| Information provided by: | National Heart, Lung, and Blood Institute (NHLBI) |
| ClinicalTrials.gov Identifier: | NCT00241683 |
Purpose
To determine whether or not women with a history of having a baby with intrauterine growth retardation (IUGR) are more likely to have risk factors for cardiovascular disease versus women with a pregnancy not complicated by IUGR.
| Condition |
|
Cardiovascular Diseases Heart Diseases |
| MedlinePlus related topics: | Heart Disease in Women Heart Diseases |
| Study Type: | Observational |
| Study Design: | Natural History, Defined Population |
| Study Start Date: | August 2005 |
| Estimated Study Completion Date: | July 2010 |
BACKGROUND:
Intrauterine growth restriction leads to major neonatal morbidity and mortality. Moreover, recent birth registry studies have suggested that women bearing IUGR babies may have an elevated risk of cardiovascular disease.
DESIGN NARRATIVE:
The cohort study will test whether exposed women, with a previous intrauterine growth restriction (IUGR) baby, versus unexposed women, with a pregnancy not complicated by IUGR, will have elevations in markers of cardiovascular risk. Exposure will be defined among a geographically defined cohort as having had a singleton baby in the < 5 %tile of weight for gestational age, in the absence of pre-pregnancy diabetes., hypertension, renal disease, or hypertension in pregnancy; controls will have had a singleton in the > 20%tile. Five to nine years postpartum, women will be assessed for multiple markers of cardiovascular risk, including blood pressure, lipids, adiposity, glucose and insulin, homocysteine and folate, markers of inflammation, markers of endothelial function, markers of angiogenesis, and markers of vascular function. Data analysis will consist of ANOVA and ANCOVA analyses comparing the outcomes of cardiovascular markers among exposed and unexposed women.
Eligibility
| Genders Eligible for Study: | Female |
| Accepts Healthy Volunteers: | No |
No eligibility criteria
Contacts and Locations More Information
| Study ID Numbers: | 1307 |
| First Received: | October 17, 2005 |
| Last Updated: | October 17, 2005 |
| ClinicalTrials.gov Identifier: | NCT00241683 |
| Health Authority: | United States: Federal Government |
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