Effective High Aerobic Intensity Endurance Training Regimes in Chronic Obstructive Pulmonary Disease (COPD) Patients - Full Text View

Purpose

4 times 4 minutes interval training with and without hyperoxia is more effective than low intensity endurance training.

Condition	Intervention
Pulmonary Disease, Chronic Obstructive Hyperoxia	Behavioral: 4 times 4 minutes high aerobic intensity one leg cycling

MedlinePlus related topics:

COPD (Chronic Obstructive Pulmonary Disease)

U.S. FDA Resources

Study Type:	Interventional
Study Design:	Treatment, Randomized, Open Label, Active Control, Parallel Assignment

Official Title:	Effective High Aerobic Intensity Interval Training to Improve Maximal Oxygen Uptake in COPD Patients

Further study details as provided by Norwegian University of Science and Technology:

Primary Outcome Measures:

VO2peak [ Time Frame: 10 weeks ] [ Designated as safety issue: No ]
Ventilation [ Time Frame: 10 weeks ] [ Designated as safety issue: No ]
FEV1 [ Time Frame: 10 weeks ] [ Designated as safety issue: No ]
Walking performance [ Time Frame: 10 weeks ] [ Designated as safety issue: No ]

Secondary Outcome Measures:

Quality of life [ Time Frame: 3 months ] [ Designated as safety issue: No ]
SPSS [ Time Frame: 3 months ] [ Designated as safety issue: No ]

Enrollment:	26
Study Start Date:	January 2004
Study Completion Date:	February 2006
Primary Completion Date:	February 2006 (Final data collection date for primary outcome measure)

Arms	Assigned Interventions
1: Active Comparator High aerobic intensity treadmill walking. 4 by 4 minutes interval training on a 5% graded treadmill at a heart rate corresponding to 85-95% of maximal heart rate. 3 times per week for 10 weeks.	Behavioral: 4 times 4 minutes high aerobic intensity one leg cycling 3 times per week for 10 weeks
2: Active Comparator 4 times 4 minutes interval training in hyperoxia - 100% oxygen	Behavioral: 4 times 4 minutes high aerobic intensity one leg cycling 3 times per week for 10 weeks
3: Active Comparator One leg at a time training 4 times 4 minutes interval training using cycling ergometer	Behavioral: 4 times 4 minutes high aerobic intensity one leg cycling 3 times per week for 10 weeks

Eligibility

Ages Eligible for Study:	20 Years to 85 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

COPD

Exclusion Criteria:

Heart disease
Walking or cycling inabilities
Other diseases

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00658853

Locations


Norway
	Norwegian University of Science and Technology
	Trondheim, Norway, NO-7489

Sponsors and Collaborators

Norwegian University of Science and Technology

Investigators


Principal Investigator:	Jan Helgerud, PhD	Norwegian University of Science and Technology

More Information

Responsible Party:	Norwegian University of Science and Technology ( Professor Jan Helgerud / Assoc. Prfessor Sigurd Steinshamn )
Study ID Numbers:	149-03
First Received:	April 10, 2008
Last Updated:	April 14, 2008
ClinicalTrials.gov Identifier:	NCT00658853
Health Authority:	Norway: Norwegian Social Science Data Services

Keywords provided by Norwegian University of Science and Technology:

COPD

training

VO2peak

performance

ventilation

high aerobic intensity treadmill walking

one leg training by cycling

Study placed in the following topic categories:

Hyperoxia

Signs and Symptoms

Lung Diseases, Obstructive

Respiratory Tract Diseases

Lung Diseases

Signs and Symptoms, Respiratory

Chronic Disease

Pulmonary Disease, Chronic Obstructive

Additional relevant MeSH terms:

Disease Attributes

Pathologic Processes

ClinicalTrials.gov processed this record on October 17, 2008

Sponsored by:	Norwegian University of Science and Technology
Information provided by:	Norwegian University of Science and Technology
ClinicalTrials.gov Identifier:	NCT00658853