• Weight, length, head circumference at 6 months
  

• Body composition at 6 months
  
• Blood pressure at six months
  

Infants born small for gestational age often show impaired growth during childhood and reduced height as adults. Infants who are breast-fed from birth show greater 'catch-up' growth during the first few months of life than those who are formula fed but it is not clear what factors in breast milk (ie protein, nucleotides, LCPUFAs) are responsible for this 'catch-up' growth. This RCT compares the effects of using an enriched formula with increased protein and modified triglyceride (palmitate predominantly in Sn-2 position) against a standard infant formula from birth to six months on infants whose birth weights are below the 20th centiles for gestational age.

Infants are measured by a research midwife within 10 days of birth (at randomisation), 8, 16 and 26 weeks of age. At randomisation consent from the mother is taken and information collected about the pregnancy, social, demographic and medical data. At this and each further visit anthropometric measurements including skinfolds will be collected in addition to blood pressure and bio-electrical impedence at six months. A sub-sample of infants will have their body composition assessed by deuterium labelled water at six months. Data on health, weaning diets and bowel function are also collected at each visit.

Inclusion Criteria:

• Infants who are formula fed from birth
• Infants whose birthweights are less than 20th centile
• Singleton births
• Gestation > 37 weeks
• Infants free from major congenital disease

Exclusion Criteria:

• Infants who are breast-fed
• Multiple births
• Birthweight > 20th centile
• Infants with congenital disease
• Gestation < 37 weeks