HLA Matching - Unrelated Umbilical Cord Blood Transplantation - Full Text View

Purpose

The aim of this protocol is to clarify the role of HLA matching in unrelated umbilical cord blood (UCB) transplantation and to identify the level of HLA matching required assuring successful outcome of unrelated UCB transplantation.

Condition	Intervention
Hematologic Diseases	Procedure: HLA typing

U.S. FDA Resources

Study Type:	Observational
Study Design:	Prospective

Official Title:	Impact of HLA Matching on Outcome in Pediatric Patients Undergoing Unrelated Umbilical Cord Blood Transplantation.

Further study details as provided by Children's Memorial Hospital:

Estimated Enrollment:	30
Study Start Date:	June 2003
Study Completion Date:	April 2006
Primary Completion Date:	April 2006 (Final data collection date for primary outcome measure)

Detailed Description:

The aim of this protocol is to clarify the role of HLA matching in unrelated umbilical cord blood (UCB) transplantation and to identify the level of HLA matching required assuring successful outcome of unrelated UCB transplantation.

The study will answer the following questions:

Is HLA matching beneficial to unrelated UCB transplantation?
Which HLA loci, HLA-A, B, C, DRB1, or BQB1 is/are important to math, or alternatively to mismatch, to improve graft survival?
Which HLA loci, HLA-A, B, C, DRB1, or BQB1 mismatches is/are "permissive mismatches" or well tolerated mismatches?
What level of typing resolution (low, intermediate, or hgh) is required to perform patient/donor H:A matching?

By studying the cells and blood of donors and recipients, we may learn more about improving the tissue matching between unrelated donors and their recipients. Also, we hope to learn if an additional level of matching testing improves the results of the transplant treatment. Increasing knowledge about tissue matching could result in the improved long-term survival of cord blood transplant recipients.

Eligibility

Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

Pediatric Patients undergoing an unrelated umbilical cord blood transplantation.

Exclusion Criteria:

Refusal to participate in study.

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00179946

Locations


United States, Illinois
	Children's Memorial Hospital
	Chicago, Illinois, United States, 60622

Sponsors and Collaborators

Children's Memorial Hospital

Investigators


Principal Investigator:	Susanna Rodriguez-Marino, M.D.	Children's Memorial Hospital

More Information

Study ID Numbers:	BMT 0603 HLA
First Received:	September 12, 2005
Last Updated:	January 14, 2008
ClinicalTrials.gov Identifier:	NCT00179946
Health Authority:	United States: Institutional Review Board

Study placed in the following topic categories:

Hematologic Diseases

ClinicalTrials.gov processed this record on October 17, 2008

Sponsored by:	Children's Memorial Hospital
Information provided by:	Children's Memorial Hospital
ClinicalTrials.gov Identifier:	NCT00179946