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Sponsored by: |
Florence Nightingale Hospital, Istanbul |
Information provided by: | Florence Nightingale Hospital, Istanbul |
ClinicalTrials.gov Identifier: | NCT00640536 |
The purpose of this study is to determine the structural and functional cardiac alterations in obstructive sleep apne (OSA) independent from systemic hypertension and their correlation to the severity of OSA.
Condition |
Sleep Apnea, Obstructive |
MedlinePlus related topics: | High Blood Pressure Sleep Apnea |
Study Type: | Observational |
Study Design: | Case Control, Prospective |
Official Title: | The Evaluation of Right Ventricular Systolic and Diastolic Function in Patients With Newly Diagnosed Obstructive Sleep Apnea Syndrome Without Hypertension |
Enrollment: | 71 |
Study Start Date: | January 2006 |
Study Completion Date: | March 2008 |
Primary Completion Date: | March 2008 (Final data collection date for primary outcome measure) |
Groups/Cohorts |
1
Newly diagnosed obstructive sleep apnea patients without hypertension
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Age, sex and and body mass index-matched matched healthy subjects
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Many risk factors for OSA, such as male gender, obesity, and increasing age are the same as for cardiovascular diseases. This fact makes it more difficult to establish a causal relationship between OSA and cardiovascular diseases. The relationship between OSA and right ventricular (RV) function is controversial. RV dysfunction may be a result of chronic intermittent hypoxia and hypercapnia during apneic episodes. It may also occur secondary to left ventricular dysfunction as a result of increased afterload and sympathetic activity which causes secondary hypertension. As systemic hypertension is one of the most accompanying and contributing factors in OSA along with obesity, we tried to compare the effects of newly diagnosed OSA on RV function with an age and body mass index- matched control group.
Ages Eligible for Study: | 18 Years to 80 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Probability Sample |
Tertiary care clinic, obstructive sleep apnea patients
Inclusion Criteria:
For OSA patients (group1)
Exclusion Criteria:
Turkey, Caglayan | |||||
Florence Nightingale Hospital | |||||
Istanbul, Caglayan, Turkey, 34381 |
Florence Nightingale Hospital, Istanbul |
Principal Investigator: | Saide Aytekin | T.C. Istanbul Bilim University, Florence Nightingale Hospital, Division of Cardiology |
Responsible Party: | T.C. Istanbul Bilim University; Florence Nightingale Hospital ( Prof. Dr. Saide Aytekin ) |
Study ID Numbers: | AT-1974/1 |
First Received: | March 17, 2008 |
Last Updated: | March 20, 2008 |
ClinicalTrials.gov Identifier: | NCT00640536 |
Health Authority: | Turkey: Ministry of Health; Turkey: Ethics Committee |
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