| Version 2.5.2.0 |
|
|
Abstract
Grant Number: 5F32AT003366-03 Project Title: CAM Approaches to Air Pollution Related Health Effects
PI Information: Name Title ALLEN, JASON drjnd@u.washington.edu Abstract: DESCRIPTION (provided by applicant): Air pollution, specifically diesel exhaust (DE), is associated with the top four causes of mortality in the United States: heart disease, cancer, stroke, and chronic lower respiratory diseases. In spite of the prevalence of these conditions and magnitude of DE exposure in ambient urban and occupational environments, few biologically based attempts have been made to thwart the effects of acute or chronic exposures. Oxidative stress is a prevailing theory in the mechanism of action of air pollutant-induced adverse health effects. Antioxidants, the body's defense against oxidative stress, are commonly employed by CAM practitioners to prevent and reduce the adverse consequences of exposure to pollutants. This research application is intended to examine a CAM product (glutathione (GSH)) and model (prevention) in an attempt to reduce oxidative stress induced by DE exposure. The UW exposure laboratory offers an unparalleled opportunity to examine CAM interventions in augmenting human responses to DE. This nested research application is a double-blind, placebo-controlled, cross-over experiment to determine if inhaled GSH can blunt the observed oxidative stress associated with controlled DE exposure. While biologically based, scientifically plausible, and currently used in the CAM community, this promising intervention lacks exposure-specific evidence. The long-term objective of this research is to rigorously examine potential CAM interventions in augmenting adverse health effects induced by pollutants that pose a substantial ongoing public health burden.
Public Health Relevance:
This Public Health Relevance is not available.Thesaurus Terms:
air pollution, alternative medicine, environmental exposure, environmental health
aerosol, engine exhaust, environment related neoplasm /cancer, glutathione, hazardous substance, heart disorder, metabolic syndrome, oxidative stress, respiratory disorder, stroke
clinical research, human subject, patient oriented research, postdoctoral investigator
Institution: UNIVERSITY OF WASHINGTON Office of Sponsored Programs SEATTLE, WA 981959472 Fiscal Year: 2007 Department: ENVIRONMENTAL AND OCCUPATIONAL HEALTH SCIS Project Start: 26-SEP-2005 Project End: 25-SEP-2009 ICD: NATIONAL CENTER FOR COMPLEMENTARY & ALTERNATIVE MEDICINE IRG: ZAT1