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Brief Summary

GUIDELINE TITLE

Detection of chronic kidney disease in patients with or at increased risk of cardiovascular disease. A science advisory from the American Heart Association Kidney and Cardiovascular Disease Council; the Councils on High Blood Pressure Research, Cardiovascular Disease in the Young, and Epidemiology and Prevention; and the Quality of Care and Outcomes Research Interdisciplinary Working Group: Developed in Collaboration With the National Kidney Foundation.

BIBLIOGRAPHIC SOURCE(S)

GUIDELINE STATUS

This is the current release of the guideline.

BRIEF SUMMARY CONTENT

 RECOMMENDATIONS
 EVIDENCE SUPPORTING THE RECOMMENDATIONS
 IDENTIFYING INFORMATION AND AVAILABILITY
 DISCLAIMER

 Go to the Complete Summary

RECOMMENDATIONS

MAJOR RECOMMENDATIONS

Definitions for the weight of the evidence (Level A-C) can be found at the end of the "Major Recommendations" field.

Class I

  1. The Modification of Diet in Renal Disease (MDRD) equation should be used to estimate glomerular filtration rate in adult patients with cardiovascular disease. Values <60 mL/min per 1.73 square meters body surface area should be regarded as abnormal. (Level of Evidence: B)

Table: MDRD Study Equations for Calculating Glomerular Filtration Rate (GFR)

MDRD 1 GFR=170X[SCr]-0.999X[Age]-0.176
X[0.762 if patient is female]X[1.18 if patient is black]
X[BUN]-0.170X[Alb]0.318
MDRD2
(Abbreviated) 		GFR=186X[SCr]-1.154X[Age]-0.203
X[0.742 if patient is female]X[1.21 if patient is black]

SCr indicates serum creatinine; BUN; blood urea nitrogen; and Alb, serum albumin.

This formula can be downloaded to a PDA by visiting http://www.kidney.org/professionals/kdoqi/cap.cfm

Class IIa

  1. The albumin-to-creatinine ratio should be used to screen for the presence of kidney damage in adult patients with cardiovascular disease. Values >30 mg albumin per 1 g creatinine should be regarded as abnormal. (Level of Evidence: B)
  2. All adult patients with cardiovascular disease should be screened for evidence of kidney disease with determinations of estimated glomerular filtration rate using the MDRD equation and albumin-to-creatinine ratio. (Level of Evidence: C)

Table: Screening for Chronic Kidney Disease (CKD)

  1. Measure serum creatinine and calculate estimated GFR by the MDRD study equation (see Table above titled "MDRD Study Equations for Calculating GFR"). If estimated GFR is <60 mL/min per 1.73 m2, repeat in 3 months.*
  2. Obtain a random ("spot") urine for albumin-to-creatinine ratio determination. If albumin-to-creatinine is >30 mg albumin/g creatinine, repeat in 3 months.*
    • If either test is positive and persists for 3 months, the patient should be considered to have CKD. Appropriate evaluation and treatment should be undertaken as recommended in clinical practice guidelines.
    • If tests are both negative, they should be repeated annually.
    • If estimated GFR is <30 mL/min per 1.73 m2 or rapidly decreasing, or if urinary albumin-to-creatinine is >300 mg albumin/g creatinine, the patient should be referred to a nephrologist.

*If clinically indicated, repeat test sooner than 3 months as well as at 3-month mark.

GFR indicates glomerular filtration rate; MDRD, Modification of Diet in Renal Disease

Definitions:

Levels of Evidence

Level A (highest): multiple randomized clinical trials

Level B (intermediate): limited number of randomized trials, nonrandomized studies, and observational registries

Level C (lowest): primary expert consensus

CLINICAL ALGORITHM(S)

None provided

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EVIDENCE SUPPORTING THE RECOMMENDATIONS

TYPE OF EVIDENCE SUPPORTING THE RECOMMENDATIONS

The type of supporting evidence is identified and graded for each recommendation (see "Major Recommendations").

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IDENTIFYING INFORMATION AND AVAILABILITY

BIBLIOGRAPHIC SOURCE(S)

ADAPTATION

Not applicable: The guideline was not adapted from another source.

DATE RELEASED

2006 Sep 5

GUIDELINE DEVELOPER(S)

American Heart Association - Professional Association
National Kidney Foundation - Disease Specific Society

SOURCE(S) OF FUNDING

American Heart Association

GUIDELINE COMMITTEE

American Heart Association Kidney and Cardiovascular Disease Council

Councils on High Blood Pressure Research, Cardiovascular Disease in the Young, and Epidemiology and Prevention

Quality of Care and Outcomes Research Interdisciplinary Working Group

COMPOSITION OF GROUP THAT AUTHORED THE GUIDELINE

Primary Authors: Frank C. Brosius, III, MD, FAHA (Chair); Thomas H. Hostetter, MD; Ellie Kelepouris, MD, FAHA; Mark M. Mitsnefes, MD; Sharon M. Moe, MD, FAHA; Michael A. Moore, MD; Subramaniam Pennathur, MD; Grace L. Smith, MPH; Peter W.F. Wilson, MD, FAHA

FINANCIAL DISCLOSURES/CONFLICTS OF INTEREST

The American Heart Association makes every effort to avoid any actual or potential conflicts of interest that may arise as a result of an outside relationship or a personal, professional, or business interest of a member of the writing panel. Specifically, all members of the writing group are required to complete and submit a Disclosure Questionnaire showing all such relationships that might be perceived as real or potential conflicts of interest.

Writing Group Disclosures

Writing Group Member Employment Research Grant Other Research Support Speakers' Bureau/Honoraria Ownership Interest Consultant/Advisory Board Other
Frank C. Brosius III University of Michigan Hospital None None None None None None
Thomas H. Hostetter University of Minnesota None None None None None None
Ellie Kelepouris Temple University Hospital None None None None National Kidney Foundation—Delaware Valley None
Mark M. Mitsnefes Cincinnati Children's Hospital None None None None None None
Sharon M. Moe Indiana University School of Medicine Amgen, Genzyme None Amgen, Genzyme None Amgen, Genzyme None
Michael A. Moore Wake Forest University School of Medicine None None None None None None
Subramaniam Pennathur University of Washington Juvenile Diabetes Research Foundation None None None None None
Grace L. Smith Yale University School of Medicine None None None None None None
Peter W.F. Wilson Medical University of South Carolina Pfizer; GlaxoSmithKline; Wyeth None None None None None

This table represents the relationships of writing group members that may be perceived as actual or reasonably perceived conflicts of interest as reported on the Disclosure Questionnaire, which all members of the writing group are required to complete and submit.

Reviewer Disclosures

Reviewer Employment
(Institution)		 Research Grant Other Research Support Speakers' Bureau/Honoraria Ownership Interest Consultant/Advisory Board Other
George Bakris Rush University Medical Center NIH; AstraZeneca; Abbott; Alteon; Boehringer-Ingelheim, GlaxoSmithKline; Merck; Novartis; Lilly; Sankyo None AstraZeneca; AusAm Abbott; Alteon; Biovail; Boehringer-Ingelheim; BMS/Sanofi; GlaxoSmithKline; Merck; Novartis; Lilly None None None
Andrew S. Levey Tufts–New England Medical Center NIH; National Kidney Foundation; Amgen None None None None Annals of Internal Medicine Editorial Board
Adeera Levin University of British Columbia None None None None National Kidney Foundation None
Stuart Linas University of Colorado/Denver Health Medical System None None AstraZeneca; Merck; Pfizer; Novartis; GlaxoSmithKline None ASN; National Kidney Foundation None
William E. Mitch Baylor College of Medicine None None None None None None
Mark Sarnak Tufts–New England Medical Center Amgen None None None None None
Judith M. Veis Washington Medical Center, MedStar Health None None None None National Kidney Foundation None

This table represents the relationships of reviewers that may be perceived as actual or reasonably perceived conflicts of interest as reported on the Disclosure Questionnaire, which all reviewers are required to complete and submit.

GUIDELINE STATUS

This is the current release of the guideline.

GUIDELINE AVAILABILITY

Electronic copies: Available from the American Heart Association Web site.

Print copies: Available from the American Heart Association, Public Information, 7272 Greenville Ave, Dallas, TX 75231-4596; Phone: 800-242-8721

AVAILABILITY OF COMPANION DOCUMENTS

The following is available:

PATIENT RESOURCES

None available

NGC STATUS

This summary was completed by ECRI on March 13, 2007. The information was verified by the guideline developer on April 20, 2007.

COPYRIGHT STATEMENT

Copyright to the original guideline is owned by the American Heart Association, Inc. (AHA). Reproduction of the AHA Guideline without permission is prohibited. Single reprint is available by calling 800-242-8721 (US only) or writing the American Heart Association, Public Information, 7272 Greenville Ave., Dallas, TX 75231-4596. Ask for reprint No. 71-0276. To purchase additional reprints: up to 999 copies, call 800-611-6083 (US only) or fax 413-665-2671; 1000 or more copies, call 410-528-4121, fax 410-528-4264, or email kgray@lww.com. To make photocopies for personal or educational use, call the Copyright Clearance Center, 978-750-8400.

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DISCLAIMER

NGC DISCLAIMER

The National Guideline Clearinghouse™ (NGC) does not develop, produce, approve, or endorse the guidelines represented on this site.

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NGC, AHRQ, and its contractor ECRI Institute make no warranties concerning the content or clinical efficacy or effectiveness of the clinical practice guidelines and related materials represented on this site. Moreover, the views and opinions of developers or authors of guidelines represented on this site do not necessarily state or reflect those of NGC, AHRQ, or its contractor ECRI Institute, and inclusion or hosting of guidelines in NGC may not be used for advertising or commercial endorsement purposes.

Readers with questions regarding guideline content are directed to contact the guideline developer.
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