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| Sponsored by: |
Uniwersytet Mikolaja Kopernika w Toruniu |
| Information provided by: | Uniwersytet Mikolaja Kopernika w Toruniu |
| ClinicalTrials.gov Identifier: | NCT00204178 |
Purpose
Measurement of reactive oxygen species production and antioxidant system status before and directly after reperfusion of the transplanted kidney and influence of oxidant stress on kidney function in 2 and 6 weeks.
| Condition | Intervention |
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Kidney Transplantation |
Behavioral: Oxidative stress in kidney transplant recipients |
| MedlinePlus related topics: | Kidney Transplantation Stress |
| Study Type: | Observational |
| Study Design: | Natural History, Cross-Sectional, Defined Population, Prospective Study |
| Official Title: | The Role of Reactive Oxygen Species in Ischaemia-Reperfusion Injury of the Transplanted Kidney |
| Estimated Enrollment: | 60 |
| Study Start Date: | April 2003 |
| Estimated Study Completion Date: | September 2005 |
Oxidative stress is one of the most important factors in ischaemia-reperfusion injury to the transplanted organ. In kidney transplant recipients following factors were measured: glutathione level, activities of glutathione peroxidase (GSH-PX), catalase (CAT) and superoxide dismutase (SOD) and superoxide anion production by granulocytes in whole blood without and after the stimulation with zymosan.
Blood was sampled from peripheral vein (before reperfusion) and directly from renal vein (5 and 15 minutes after reperfusion).
Transplanted kidney function was evaluated by the incidence and length of Delayed Graft Function and serum creatinine level in 2 and 6 weeks after transplantation.
Eligibility
| Ages Eligible for Study: | 18 Years and older |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Contacts and Locations| Poland | |||||
| Klinika Transplantologii, Szpital Uniwersytecki, ul. M. Sklodowskiej-Curie 9 | |||||
| Bydgoszcz, Poland, 85-094 | |||||
| Uniwersytet Mikolaja Kopernika w Toruniu |
| Study Director: | Zbigniew Wlodarczyk, MD,PhD | Klinika Transplantologii Collegium Medicum UMK w Toruniu |
More Information
| Study ID Numbers: | KB/38/2003 |
| First Received: | September 13, 2005 |
| Last Updated: | November 30, 2005 |
| ClinicalTrials.gov Identifier: | NCT00204178 |
| Health Authority: | Poland: Ministry of Health |
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