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Sponsors and Collaborators: |
University of Glasgow Chief Scientists Office |
Information provided by: | University of Glasgow |
ClinicalTrials.gov Identifier: | NCT00411320 |
Smokers with asthma display a relative insensitivity to inhaled and oral corticosteroids. The causes of this phenomenon are currently unknown. The investigators will perform a number of blood & breathing tests to try to discover the cause/s behind this phenomenon with the aim of producing leads for further investigation and possible new treatments for smokers with asthma.
Condition | Intervention |
Asthma Smoking Steroid Resistance Corticosteroid Insensitivity |
Drug: oral steroid-dexamethasone |
MedlinePlus related topics: | Asthma Smoking |
ChemIDplus related topics: | Dexamethasone Dexamethasone acetate Dexamethasone Sodium Phosphate Doxiproct plus Corticosteroids |
Study Type: | Observational |
Study Design: | Other, Prospective |
Official Title: | Determinants of Corticosteroid Insensitivity in Smokers With Asthma |
RNA extraction from peripheral blood
Enrollment: | 53 |
Study Start Date: | January 2007 |
Study Completion Date: | September 2008 |
Primary Completion Date: | August 2008 (Final data collection date for primary outcome measure) |
Groups/Cohorts | Assigned Interventions |
Group 1
Smokers with asthma
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Drug: oral steroid-dexamethasone
2 week steroid trial
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Group 2
Ex-smokers with asthma
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Drug: oral steroid-dexamethasone
2 week steroid trial
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Group 3
Non-smokers with asthma
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Drug: oral steroid-dexamethasone
2 week steroid trial
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Smokers with asthma display a relative insensitivity to inhaled and oral corticosteroids. The causes of this phenomenon are currently unknown. However research into steroid resistance in severe asthma and the smoking related condition chronic obstructive pulmonary disease (COPD) points to a number of possible causes. We will characterise a group of smokers with asthma and perform a number of investigations and compare the results to ex-smokers and never smokers with asthma with the aim of establishing which previously published steroid resistance phenomena are related to the steroid resistance displayed by smokers with asthma. Results produced from this trial will provide hypothesis generating information leading to future pharmaceutical trials.
Ages Eligible for Study: | 18 Years to 60 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Sampling Method: | Non-Probability Sample |
Asthmatics
Inclusion Criteria:
Smoking history consistent with group
Exclusion Criteria:
United Kingdom, Scotland | |||||
Asthma Research Unit, Glasgow University | |||||
Glasgow, Scotland, United Kingdom, G12 0YN |
University of Glasgow |
Chief Scientists Office |
Principal Investigator: | Mark Spears, MRCP | University of Glasgow |
Principal Investigator: | Neil C Thomson, FRCP | University of Glasgow |
Principal Investigator: | Rekha Chaudhuri, MD | University of Glasgow |
unit website 
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Responsible Party: | NHS Greater Glasgow and Clyde (North Glasgow University Hospitals Division) ( Dr Caroline Watson, R&D Manager ) |
Study ID Numbers: | AR002 |
First Received: | December 12, 2006 |
Last Updated: | September 11, 2008 |
ClinicalTrials.gov Identifier: | NCT00411320 |
Health Authority: | United Kingdom: Research Ethics Committee |
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