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Sponsored by: |
National Human Genome Research Institute (NHGRI) |
Information provided by: | National Institutes of Health Clinical Center (CC) |
ClinicalTrials.gov Identifier: | NCT00340626 |
In a collaborative effort with the IBN AL-NAFEES Hospital (Damascus, Syrian Arab Republic), individuals from multiplex families determined to have hereditary oral clefts will be studied. The purpose of this study is to identify the gene(s) involved in heritable oral clefts by linkage analysis and gene mapping strategies. Characterization of genes involved in inherited oral clefts could provide important insight into the inheritance and pathogenesis of this disease.
Condition |
Hereditary Oral Clefts |
MedlinePlus related topics: | Cleft Lip and Palate |
Study Type: | Observational |
Official Title: | Genetic Analysis of Hereditary Non-Syndromic Oral Clefts |
Estimated Enrollment: | 1000 |
Study Start Date: | June 1997 |
In a collaborative effort with the IBN AL-NAFEES Hospital (Damascus, Syrian Arab Republic), individuals from multiplex families determined to have hereditary oral clefts will be studied. The purpose of this study is to identify the gene(s) involved in heritable oral clefts by linkage analysis and gene mapping strategies. Characterization of genes involved in inherited oral clefts could provide important insight into the inheritance and pathogenesis of this disease.
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Enrollment in this study will be limited to individuals with non-syndromic unilateral or bilateral cleft lip with or without cleft palate and their unaffected relatives, from families which meet the following criteria:
EXCLUSION CRITERIA:
Families with syndromic forms of oral clefts.
Individuals unable to provide consent, except for cases who are children and mentally impaired persons with consenting parents or guardians.
Contact: Joan Bailey-Wilson, Ph.D. | (410) 550-7509 | jebw@nhgri.nih.gov |
United States, Massachusetts | |||||
Boston University | Recruiting | ||||
Boston, Massachusetts, United States, 02118-2354 | |||||
Syrian Arab Republic | |||||
IBN Al Nafees Hospital | Recruiting | ||||
Damascus, Syrian Arab Republic |
Study ID Numbers: | 999997035, OH97-HG-N035 |
First Received: | June 19, 2006 |
Last Updated: | July 18, 2008 |
ClinicalTrials.gov Identifier: | NCT00340626 |
Health Authority: | United States: Federal Government |
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