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Sponsors and Collaborators: |
University of California, San Francisco Environmental Protection Agency (EPA) |
Information provided by: | University of California, San Francisco |
ClinicalTrials.gov Identifier: | NCT00739921 |
The objective of this study is to determine whether the amount or type of fungal DNA present in the nose and home environment can be correlated with the outcomes of the following quality of life (QOL) instruments: Medical Outcomes Study 36-item Short Form (SF-36) and the Sino-Nasal Outcomes Study - 20 Questions (SNOT-20).
Condition | Intervention |
Sinusitis Nasal Polyps |
Procedure: Nasal swab under endoscopic guidance |
MedlinePlus related topics: | Molds Sinusitis |
Study Type: | Interventional |
Study Design: | Diagnostic, Open Label, Parallel Assignment |
Official Title: | PCR Analysis of Nasal Polyps for Fungal DNA |
Estimated Enrollment: | 187 |
Study Start Date: | June 2006 |
Estimated Study Completion Date: | October 2009 |
Estimated Primary Completion Date: | July 2009 (Final data collection date for primary outcome measure) |
Arms | Assigned Interventions |
1: Experimental
Patients with sinusitis compared to patients without.
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Procedure: Nasal swab under endoscopic guidance
Patients with and without sinusitis will have a nasal swab taken under endoscopic guidance from their nose (middle meatus) after the application of pontocaine and neosynephrine spray. The swab will be refrigerated and analyzed using PCR to detect and speciate fungus.
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The objective of this study is to determine whether the amount or type of fungal DNA present in the nose and home environment can be correlated with the outcomes of the following quality of life (QOL) instruments: Medical Outcomes Study 36-item Short Form (SF-36) and the Sino-Nasal Outcomes Study - 20 Questions (SNOT-20).
The study design involves case control Polymerase Chain reaction (PCR) analysis of nasal mucosal swabs and home vacuum cleaner bags in patients with sinusitis and normal controls.
The hypothesis is that the quantity and type of fungal DNA present in the nose and home environment are directly correlated with quality of life. Our research aims to both quantify the amount of fungi present in the nasal mucosa as well as to measure the severity of the patient's chronic rhinosinusitis (CRS) as a function of SNOT-20 and SF-36 outcomes questionnaires. We hypothesize that the amount and type of fungi present in the nose and home environment will correlate with the severity of the patients' symptoms of CRS.
Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
Contact: Wendy Ma | 415-353-2870 | wma@ohns.ucsf.edu |
Contact: Andrew Murr, MD | 415-353-2870 | ahmurr@ohns.ucsf.edu |
United States, California | |||||
University of California, San Francisco, Dept of Otolaryngology-HNS | Recruiting | ||||
San Francisco, California, United States, 94143 | |||||
Contact: Wendy Ma 415-353-2870 wma@ohns.ucsf.edu | |||||
Contact: Andrew Murr, MD 415-353-2870 ahmurr@ohns.ucsf.edu | |||||
Principal Investigator: Andrew Murr, MD | |||||
Sub-Investigator: Andrew Goldberg, MD, MSCE |
University of California, San Francisco |
Environmental Protection Agency (EPA) |
Principal Investigator: | Andrew Murr, MD | University of California, San Francisco |
Responsible Party: | University of California, San Francisco ( Andrew Murr, MD ) |
Study ID Numbers: | H9272-26987-04 |
First Received: | August 19, 2008 |
Last Updated: | August 20, 2008 |
ClinicalTrials.gov Identifier: | NCT00739921 |
Health Authority: | United States: Institutional Review Board |
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