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Sponsored by: |
University of Calgary |
Information provided by: | University of Calgary |
ClinicalTrials.gov Identifier: | NCT00739895 |
Cardiovascular magnetic resonance (CMR) imaging will be used to assess the impact of common colds and physical training in high-performing athletes. Healthy individuals from the general public will serve as a comparison group. CMR has previously been shown to accurately assess cardiac function, edema, inflammation, and injury.
Athletes competing at National level and Developmental Canadian teams will be prospectively recruited. All participants will have CMR scans at low and high intensity training. Participants will be re-scanned immediately after clinical evidence of a common cold, as determined by respiratory and flu-like symptoms. After 4 weeks, a follow-up CMR scan will be performed. On the day of each CMR scan, electrocardiograms and blood samples will be drawn from each participant. Blood samples will provide markers of systemic inflammation, such as leukocyte counts. At each CMR scan, athletes will be asked to describe there recent history of physical exertion in questionnaires, which will reflect the degree of physical exertion performed.
Condition | Intervention |
Ventricular Function, Left |
Procedure: Cardiac magnetic Resonance study Procedure: Blood testing |
MedlinePlus related topics: | Common Cold Edema MRI Scans Nuclear Scans |
Study Type: | Observational |
Study Design: | Case Control, Prospective |
Official Title: | Left Ventricular Dilatation in Athletes With Common Colds; a Cardio-Vascular MRI Study |
Estimated Enrollment: | 100 |
Study Start Date: | June 2007 |
Estimated Study Completion Date: | June 2009 |
Estimated Primary Completion Date: | November 2008 (Final data collection date for primary outcome measure) |
Groups/Cohorts | Assigned Interventions |
Athletes
high performing athletes
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Procedure: Cardiac magnetic Resonance study
follow-up studies
Procedure: Blood testing
Blood sample tested for myocardial biomarkers
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Cardiovascular magnetic resonance (CMR) imaging will be used to assess the impact of a common colds and physical training in high-performing athletes. Healthy individuals from the general public will serve as a comparison group. CMR has previously been shown to accurately assess cardiac function, edema, inflammation, and injury.
Athletes competing at National level and Developmental Canadian teams will be prospectively recruited. All participants will have CMR scans at low and high intensity training. Participants will be re-scanned immediately after clinical evidence of a common cold, as determined by respiratory and flu-like symptoms. After 4 weeks, a follow-up CMR scan will be performed. On the day of each CMR scan, electrocardiograms and blood samples will be drawn from each participant. Blood samples will provide markers of systemic inflammation, such as leukocyte counts. At each CMR scan, athletes will be asked to describe there recent history of physical exertion in questionnaires, which will reflect the degree of physical exertion performed.
Image analysis: CMR parameters that serve as surrogate markers for myocardial inflammation will be assessed. Specifically, they include STIR (edema), early enhancement (inflammation), and late enhancement (fibrosis). The presence of 2 of these parameters will indicate the presence of myocardial inflammation. Qualitative and quantitative analysis will be performed on images obtained from CMR scans, and will be assessed offline using CMR42 (Circle International, Calgary) software. Standard methods of assessing edema, inflammation, and fibrosis will be implemented. Standard left ventricular function volume analysis techniques will be implemented to assess left ventricular dilatation.
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Non-Probability Sample |
high performance athletes, during acute viremia and at variable training intensities. Healthy individuals from the general public will serve as a reference group.
Inclusion Criteria:
Exclusion Criteria:
Canada, Alberta | |||||
Stephenson CMR Centre at Foothills Medical Centre, University of Calgary | |||||
Calgary, Alberta, Canada, T2N 2T9 |
University of Calgary |
Principal Investigator: | Matthias G Friedrich, MD, FESC | University of Calgary |
Responsible Party: | University of Calgary ( University of Calgary ) |
Study ID Numbers: | Athletes_001 |
First Received: | August 20, 2008 |
Last Updated: | August 21, 2008 |
ClinicalTrials.gov Identifier: | NCT00739895 |
Health Authority: | Canada: Health Canada |
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