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| Sponsors and Collaborators: |
University of Pennsylvania University of Iowa |
| Information provided by: | University of Pennsylvania |
| ClinicalTrials.gov Identifier: | NCT00647335 |
Purpose
The purpose of this study is to look at genes (DNA) and how they affect health and disease. Genes are the instruction manual for the body. The genes you get from your parents decide what you look like and how your body behaves. They can also tell us a person's risk for certain diseases and how they will respond to treatment. We will collect a saliva sample for genetic research
| Condition |
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PCOS |
| Study Type: | Observational |
| Study Design: | Case-Only, Prospective |
| Official Title: | Population Genetics of Polycystic Ovary Syndrome |
Saliva
| Estimated Enrollment: | 300 |
| Study Start Date: | February 2008 |
| Estimated Study Completion Date: | December 2010 |
| Estimated Primary Completion Date: | December 2010 (Final data collection date for primary outcome measure) |
| Groups/Cohorts |
|
1
Women with diagnosis of PCOS
|
Polycystic ovary syndrome (PCOS) is a common endocrine disorder of women, characterized by elevated levels of male hormones, absent menstruation, infrequent or very light menstruation, and reduced ability to reproduce. Genetic factors likely contribute to the etiology of PCOS, but no genes have been identified with certainty. The findings from these studies will enhance our understanding of the genetics of PCOS, a major contributor to female infertility. Better knowledge of "PCOS genes" will also help in predicting responses to treatments for infertility, insulin resistance, and other aspects of the disease.
Women with PCOS may be eligible to participate in this study if they are between the ages of 18 and 50 and have two living biological parents who are also willing to participate. Study participation involves telephone screening and consent and home collection by subjects (probands) and their parents of sputum (saliva) in a provided container. Specimen containers and signed consent forms will be returned to the study site by mail.
The major goal of this research project, the identification of genes contributing to PCOS, will provide basic understanding of the genotype-phenotype relationships that contribute to features of PCOS. Knowledge of "PCOS genes" would assist physicians in predicting and assessing responses to interventions that promote fertility, improve insulin sensitivity, and treat other aspects of the disease.
Eligibility
| Genders Eligible for Study: | Female |
| Accepts Healthy Volunteers: | No |
| Sampling Method: | Non-Probability Sample |
Women with a diagnosis of PCOS undergoing treatment at University of Pennsylvania and University of Iowa.
Inclusion Criteria:
Exclusion Criteria:
Contacts and Locations| Contact: Linda R Martino, CRNP | (215) 615-3664 | lmartino@obgyn.upenn.edu |
| United States, Pennsylvania | |||||
| University of Pennsylvania | Recruiting | ||||
| Philadelphia, Pennsylvania, United States, 19104 | |||||
| Contact: Linda R Martino, CRNP 215-615-3664 lmartino@obgyn.upenn.edu | |||||
| Principal Investigator: Anjua Dokras-Jagasia, MD, PhD | |||||
| University of Pennsylvania |
| University of Iowa |
| Principal Investigator: | Anuja Dokras-Jagasia, MD, PhD | University of Pennsylvania |
| Principal Investigator: | Brad V Voorhis, MD | University of Iowa |
More Information
| Responsible Party: | University of Pennsylvania ( Anuja Dokras-Jagasia ) |
| Study ID Numbers: | 807101, University of IOWA# 200707772 |
| First Received: | March 26, 2008 |
| Last Updated: | July 21, 2008 |
| ClinicalTrials.gov Identifier: | NCT00647335 |
| Health Authority: | United States: Institutional Review Board |
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