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| Sponsors and Collaborators: |
Hvidovre University Hospital University of Copenhagen |
| Information provided by: | Hvidovre University Hospital |
| ClinicalTrials.gov Identifier: | NCT00647023 |
Purpose
The incretin hormones are secreted from the gastrointestinal tract in response to nutrient ingestion, and are responsible for 70 % of insulin secretion in response to glucose. The incretin response is attenuated in subjects with type 2 diabetes and other conditions associated with insulin resistance. Polycystic ovary syndrome (PCOS) is characterised by irregular periods and increased androgen levels. It is the most common endocrine disorder amongst young women at fertile age, and the most common cause of female infertility. Insulin resistance plays an important role in the development of the disease, and women with PCOS are at increased risk of developing tyoe 2 diabetes. the incretin hormones have not previously been investigated in women with PCOS, and the purpose of the present study was to investigate the secretion of the two most important incretin hormones Glucose-like peptide-1 (GLP-1) and Glucose dependent insulinotropic peptide (GIP) during a three hour oral glucose tolerance test.
| Condition | Intervention |
|
Polycystic Ovary Syndrome |
Drug: metformin |
| MedlinePlus related topics: | Diabetes |
| ChemIDplus related topics: | Metformin Metformin hydrochloride |
| Study Type: | Interventional |
| Study Design: | Basic Science |
| Enrollment: | 66 |
| Study Start Date: | February 2004 |
| Study Completion Date: | May 2006 |
| Primary Completion Date: | May 2006 (Final data collection date for primary outcome measure) |
| Arms | Assigned Interventions |
| A: Experimental |
Drug: metformin
1000 mg metformin x 2 daily during 8 months
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Eligibility
| Ages Eligible for Study: | 18 Years to 38 Years |
| Genders Eligible for Study: | Female |
| Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
Contacts and Locations More Information
| Responsible Party: | Pernille Fog Svendsen ( Incretin secretion in women with PCOS ) |
| Study ID Numbers: | Incretins and PCOS |
| First Received: | March 26, 2008 |
| Last Updated: | March 26, 2008 |
| ClinicalTrials.gov Identifier: | NCT00647023 |
| Health Authority: | Denmark: The Regional Committee on Biomedical Research Ethics |
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