| | Staff Scientists and Clinicians
| Thomas M. Hyde, M.D., Ph.D. |
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Dr. Hyde from the University of Pennsylvania in 1978, with a B.A. in Biology. He then entered the M.D.
-Ph.D. combined degree program at the University of Pennsylvania, graduating in 1984 with a Ph.D. in
Anatomy. His medical and graduate school education were funded with an award from the Medical
Scientist Training Program. Dr. Hyde completed a general medical internship at the Presbyterian-University
of Pennsylvania in 1985. He then moved on to Stanford University, completing a residency in Neurology
in 1988. He served as Chief Resident in Neurology at Stanford in 1988. In 1990, he was board certified in
Neurology. In 1988, Dr. Hyde became director of the Neurology Consultation Clinics of the NIMH
Neuroscience Center at St. Elizabeths Hospital, serving until 1996. He also worked collaboratively in the
Neuropathology Section of the Clinical Brain Disorders Branch, IRP, NIMH from 1988-1996. In 1996, Dr.
Hyde became a full time investigator in the Neuropathology Section of the Clinical Brain Disorders
Branch. In addition, he has served as a Neurology Consultant to the clinical programs of the Clinical Brain
Disorders Branch, IRP, NIMH.
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| Research Interests |
| Dr.
Hyde is focused upon the neuropathological bases of major
mental illnesses, especially schizophrenia. In the past,
he has worked on a variety of laboratory-based projects
examining receptor, neurotransmitter, and growth factor
systems in post-mortem human brain, employing a wide variety
of techniques. He is currently focused on the application
of microarrays and laser capture microscopy to post-mortem
human brain tissue in general and schizophrenia in particular.
He also maintains clinical research activities in the
Sibling Study of the Genetics of Schizophrenia, movement
disorders, and dementia. |
| Representative Selected Recent Publications: |
- Vawter, M.P., J.M. Crook, T.M. Hyde, J.E. Kleinman, D.R. Weinberger, K.G. Becker, and W.J. Freed.: Microarray analysis of gene expression in the prefrontal cortex in schizophrenia. Schizophrenia Research, 7: 571-578, 2002.
- Hamid, E.H., T. M. Hyde, S.E. Bachus, M.F. Egan, B. Kinkead, C.B. Nemeroff, and J.E. Kleinman.: Neurotensin receptor abnormalities in the mesial temporal lobe in schizophrenia. Biological Psychiatry, 15: 795-800, 2002.
- Egan, M.F., T.M. Hyde, J.B. Bonomo, V.S. Mattay, L.B. Bigelow, T.E. Goldberg, and D.R. Weinberger. Relative risk of neurological signs in siblings of patients with schizophrenia. American Journal of Psychiatry, 158: 1827-1834, 2002.
- Hyde, T.M., S. Nawroz, T.E. Goldberg, D. Strong, J.L. Ostrem, D.R. Weinberger, and J.E. Kleinman.: Is there cognitive decline in schizophrenia? A cross-sectional study. British Journal of Psychiatry, 164: 494-500, 1994.
- Hyde, T.M., J.C. Ziegler, and D.R. Weinberger.: Psychiatric disturbances in metachromatic leukodystrophy: insights into the neurobiology of psychosis. Archives of Neurology, 49: 401-406, 1992.
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