• To determine the time to treatment termination due to disease progression or toxicity [ Time Frame: every 3 months ] [ Designated as safety issue: No ]
  

• To determine the toxicity of this therapy [ Time Frame: every 2 weeks ] [ Designated as safety issue: Yes ]
  
• To determine the development of anti-Trag antibodies [ Time Frame: every 2 months ] [ Designated as safety issue: No ]
  

Drug: GM-CSF, Leukine
GM-CSF 150 mcg given subcutaneously daily without interruption

This is an open labeled, single arm phase II study of GM-CSF delivered daily without a break in a population of healthy and fit women with evidence of recurrent but asymptomatic mullerian malignancy (such as ovarian cancer, fallopian tube cancer, or primary peritoneal cancer). The main goal is to determine the time to treatment termination due to disease progression or toxicity.

Inclusion Criteria:

Patients must have a history of histologic or cytologic diagnosis of primary ovarian, primary peritoneal or tubal carcinoma.

Patients must be asymptomatic from their cancer.

Patients must have evidence of recurrent carcinoma, as determined by:

• A rising CA-125 serum level greater than 35 U/mL or two successive rising values with the most recent value at least 3 times the nadir value.
• Or evidence of evaluable or measurable disease by x-ray or CT scan. Patients may not receive concurrent antineoplastic therapy. All hormonal therapy used as a treatment modality (i.e. tamoxifen, arimidex, etc) must be stopped prior to treatment on protocol.

Age > 18 years. ECOG performance status< 2

Exclusion Criteria:

Known severe hypersensitivity to GM-CSF Other coexisting malignancies or malignancies diagnosed within the last 5 years, with the exception of basal cell carcinoma or cervical cancer in situ or concurrent superficial or stage IB endometrial carcinoma Concomitant use of anti-neoplastic therapy Treatment with a non-FDA approved or investigational drug within 30 days before Day 1 of trial treatment Any unresolved chronic toxicity greater then CTC grade 2 from previous anticancer therapy (except alopecia) Serum creatinine level greater than CTC grade 2 (£ 1.5 x ULN) Pregnancy or breast feeding (women of childbearing potential) Severe or uncontrolled systemic disease (e.g., unstable or uncompensated respiratory, cardiac, hepatic, or renal disease) as judged by the investigator.

Significant clinical disorder or laboratory finding that makes it potentially unsafe for the subject to participate in the trial as judged by the investigator.

Patients currently receiving other investigational antineoplastic agents, on systemic chemotherapy or under radiation therapy treatment.

Patients with clinical and/or radiographic evidence of current or impending bowel obstruction.

Performance status < 1 Ability to understand and the willingness to sign a written informed consent document.