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Sponsors and Collaborators: |
UMC Utrecht Netherlands Organisation for Scientific Research De Hersenstichting (The Dutch Brain Foundation) |
Information provided by: | UMC Utrecht |
ClinicalTrials.gov Identifier: | NCT00156221 |
The specific is to study the MR morphologic and spectroscopic brain correlates and predictors of development in children with severe developmental disorders (autistic spectrum disorders and/or mental retardation and/or language disorders). Given the frequently observed association of autism with known medical conditions, particularly in cases with comorbid mental retardation and in cases with atypical autism (Rutter et al., 1994; Gillberg, 1995), children with suspected autism or related developmental disorders will be asked to participate in an extensive state of the art laboratory work-up which includes T1 and T2 weighted MRI of the brain. MRI data will be analyzed both qualitatively, looking for focal abnormalities and degree of myelination, and quantitatively, measuring volumes of total brain, cerebellum, ventricles and grey and white matter. For research purposes, the work-up will be supplied with proton Magnetic Resonance Spectroscopy (MRS) of the brain. This data set provides the opportunity to chart brain-behavior relationships in young children with suspected autism and related PDD cross-sectionally.
Condition |
Autism Mental Retardation Language Disorder |
MedlinePlus related topics: | Autism Developmental Disabilities Nuclear Scans |
Study Type: | Observational |
Study Design: | Natural History, Cross-Sectional, Convenience Sample, Retrospective/Prospective Study |
Official Title: | MR Scanning of Very Young Children With Severe Developmental Disorders (Autistic Spectrum Disorders and/or Mental Retardation and/or Language Disorders) |
Ages Eligible for Study: | 18 Months to 7 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Netherlands | |||||
UMC Utrecht | |||||
Utrecht, Netherlands, 3508 GA |
UMC Utrecht |
Netherlands Organisation for Scientific Research |
De Hersenstichting (The Dutch Brain Foundation) |
Study Chair: | Herman van Engeland, PhD, MD | UMC Utrecht |
Principal Investigator: | Mijke Zeegers, Msc | UMC Utrecht |
Study ID Numbers: | METC UMC Utrecht 99/184 |
First Received: | September 8, 2005 |
Last Updated: | September 8, 2005 |
ClinicalTrials.gov Identifier: | NCT00156221 |
Health Authority: | Netherlands: The Central Committee on Research Involving Human Subjects (CCMO) |
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