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Sponsored by: |
Department of Veterans Affairs |
Information provided by: | Department of Veterans Affairs |
ClinicalTrials.gov Identifier: | NCT00732199 |
The purpose for our research protocol is to examine the role of breathing control mechanisms that determine the development of sleep-disordered breathing in the elderly. This proposal will focus on key factors that contribute to the control of ventilation in healthy individuals and in subjects with sleep-disordered breathing. We will study the age-specific changes in both normal persons and sleep individuals with sleep apnea.
Condition | Intervention |
Sleep Apnea |
Other: hyperventilation and episodic hypoxia |
MedlinePlus related topics: | Sleep Apnea |
Study Type: | Interventional |
Study Design: | Diagnostic, Non-Randomized, Open Label, Parallel Assignment, Efficacy Study |
Official Title: | Determinants of Age-Specific Breathing Instability During Sleep |
Estimated Enrollment: | 100 |
Study Start Date: | October 2008 |
Estimated Study Completion Date: | September 2013 |
Estimated Primary Completion Date: | July 2013 (Final data collection date for primary outcome measure) |
Arms | Assigned Interventions |
1
Young adults, > age 18 yrs
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Other: hyperventilation and episodic hypoxia
noninvasive hyperventilation to determine apneic thresholdhypoxia to determine long term facilitation
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2: Experimental
Old adults, age >60-65yrs
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Other: hyperventilation and episodic hypoxia
noninvasive hyperventilation to determine apneic thresholdhypoxia to determine long term facilitation
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Sleep apnea-hypopnea syndrome (SAS) is a relatively common disorder in the US population with significant adverse health consequences. Despite the high prevalence of SAS in elderly individuals, the underlying mechanisms have remained elusive. Specifically, we do not know whether the high prevalence of sleep apnea in older adults is due to increased central breathing instability. This proposal focuses on investigating age-specific differences in the susceptibility to central breathing instability in healthy individuals as well as individuals with sleep apnea.
This project will investigate the following specific objectives:
Determine age-specific changes in the hypocapnic apneic threshold during sleep in
Determine age-specific changes in long-term facilitation during sleep in
Sleep apnea is very common in older veterans and is associated with significant cardiovascular complications. Greater insight into the pathogenesis will have a positive impact on the health of veterans suffering from this condition.This proposal will further our understanding of the pathogenesis of breathing instability leading to sleep-disordered breathing during sleep. Thus, we anticipate our findings will provide a basis for new approaches to prevention and management of SAS in veterans.
Ages Eligible for Study: | 18 Years to 89 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
Contact: Susmita Chowdhuri, MD | (313) 576-1000 ext 63685 | schowdh@med.wayne.edu |
Contact: Sukanya Pranathiageswaran, MS | (313) 576-3548 | spranath@med.wayne.edu |
United States, Michigan | |||||
John D. Dingell VA Medical Center, Detroit | Not yet recruiting | ||||
Detroit, Michigan, United States, 48201 | |||||
Contact: Mary Ann Uhrin, BS 313-576-1000 ext 64474 maryann.uhrin@med.va.gov | |||||
Principal Investigator: Susmita Chowdhuri, MD |
Principal Investigator: | Susmita Chowdhuri, MD | John D. Dingell VA Medical Center, Detroit |
Responsible Party: | Department of Veterans Affairs ( Chowdhuri, Susmita - Principal Investigator ) |
Study ID Numbers: | CDA-2-019-07F |
First Received: | August 7, 2008 |
Last Updated: | August 8, 2008 |
ClinicalTrials.gov Identifier: | NCT00732199 |
Health Authority: | United States: Federal Government |
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