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| Sponsors and Collaborators: |
Weill Medical College of Cornell University Department of Genetic Medicine |
| Information provided by: | Weill Medical College of Cornell University |
| ClinicalTrials.gov Identifier: | NCT00362739 |
Purpose
This is a research study where researchers are collecting blood to evaluate the genetic characteristics of individuals with chronic lung diseases, including asthma, COPD (chronic obstructive pulmonary disease), interstitial lung disease, cystic fibrosis, and lung cancer. We hope to be able to identify an association between a genetic make-up in the blood samples and the risks of developing a particular lung disease, or severity of a lung disease. The findings of this study might be important to develop future preventative methods and potential treatments for the management of lung disease. We aim to collect blood samples from 300 people with lung disease and 300 controls over 5 years.
| Condition |
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Asthma COPD Interstitial Lung Disease Cystic Fibrosis Lung Cancer |
| Genetics Home Reference related topics: | cystic fibrosis |
| MedlinePlus related topics: | Asthma Cancer Cystic Fibrosis Lung Cancer |
| Study Type: | Observational |
| Study Design: | Case Control, Prospective |
| Official Title: | Collection of Blood for Gene Expression/Genomic Studies in Individuals With Chronic Lung Disease |
In this study, a small amount of blood for extraction of DNA for the study of the genetic basis of lung disease will be obtained from each subject. The collected blood (cells and serum) will be used for genetic testing in studies relating to the genetic material and/or gene expression, and/or studies of proteins or other substances in serum (the liquid portion of the blood after it has been allowed to clot). Because these latter protein studies will occur at a future date, the serum will be stored for use in these studies.
| Estimated Enrollment: | 600 |
| Study Start Date: | September 2005 |
| Groups/Cohorts |
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1: Lung Disease
Individuals with at least one of the following: (1) symptoms consistent with pulmonary disease; (2) chest X-ray consistent with lung disease; (3) pulmonary function tests consistent with lung disease; (4) lung biopsy consistent with lung disease; (5) family history of lung disease; (6) patients with diseases of organs with known association with lung disease; (7) individuals suspected of history of lung diseased based on history and/or physical examination
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2: Normal Controls
Individuals without a history of lung disease
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Eligibility
| Ages Eligible for Study: | 18 Years and older |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
| Sampling Method: | Non-Probability Sample |
Individuals visiting the Starr-5 Pulmonary, Critical Care Unit, and 5 West floor for standard clinical care will be recruited. Controls will be obtained from volunteers without a history of lung disease.
Inclusion Criteria:
Exclusion Criteria:
Contacts and Locations| Contact: Charleen Hollmann, PhD, MPA, RN | 646-962-2672 | chollman@med.cornell.edu |
| Contact: Mary Yeotsas, BA | 646-962-2672 | mey2003@med.cornell.edu |
| United States, New York | |||||
| New York Presbyterian Hospital -- Weill Cornell Mecial College of Cornell University | Recruiting | ||||
| New York, New York, United States, 10021 | |||||
| Principal Investigator: Ronald G Crystal, MD | |||||
| Weill Medical College of Cornell University |
| Department of Genetic Medicine |
| Principal Investigator: | Ronald G Crystal, MD | The New York Presbyterian Hospital -- Weill Medical College of Cornell University |
More Information
| Responsible Party: | Weill Cornell Medical College, Department of Genetic Medicine ( Dr. Ronald G. Crystal ) |
| Study ID Numbers: | 0508008095 |
| First Received: | August 8, 2006 |
| Last Updated: | September 15, 2008 |
| ClinicalTrials.gov Identifier: | NCT00362739 |
| Health Authority: | United States: Institutional Review Board |
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