Chlamydia Trachomatis Persistence in the Female Gastrointestinal Tract - Full Text View

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Chlamydia Trachomatis Persistence in the Female Gastrointestinal Tract

This study has been withdrawn prior to recruitment.
( Study redesigned and re-submitted to UAMS IRB under different study title and IRB number. )

Sponsored by:	Arkansas Children's Hospital Research Institute
Information provided by:	Arkansas Children's Hospital Research Institute
ClinicalTrials.gov Identifier:	NCT00578188

Purpose

The purpose of this study is to determine if Chlamydial infections persist in the rectum of females who have had a sexually transmitted infection of Chlamydia.

Condition

Chlamydia Infection

MedlinePlus related topics:

Chlamydia Infections

U.S. FDA Resources

Study Type:	Observational
Study Design:	Case Control, Prospective

Official Title:	Chlamydia Trachomatis Persistence in the Female Gastrointestinal Tract

Further study details as provided by Arkansas Children's Hospital Research Institute:

Biospecimen Retention: Samples With DNA

Biospecimen Description:

Serum, whole blood, tissue

Estimated Enrollment:	300
Study Start Date:	February 2006
Estimated Study Completion Date:	January 2008
Estimated Primary Completion Date:	January 2008 (Final data collection date for primary outcome measure)

Groups/Cohorts

RP100-400

Subjects with Chlamydia. The control group will also be identified with these numbers.

Eligibility

Ages Eligible for Study:	11 Years to 19 Years
Genders Eligible for Study:	Female
Accepts Healthy Volunteers:	Yes
Sampling Method:	Non-Probability Sample

Study Population

11-19 year old females from the Arkansas Children's Hospital Adolescent Center

Criteria

Inclusion Criteria:

11-19 years old
Female
Diagnosis of Chlamydia on enrollment visit
Invitation to participate control group

Exclusion Criteria:

Age out of range
Negative Chlamydia screen (unless qualifies for control group)
Unable to provide needed samples

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00578188

Locations


United States, Arkansas
	Arkansas Children's Hospital
	Little Rock, Arkansas, United States, 72202

Sponsors and Collaborators

Arkansas Children's Hospital Research Institute

Investigators


Principal Investigator:	Amy M Scurlock, MD	Arkansas Children's Hospital Research Institute

More Information

Arkansas Children's Hospital Main Page This link exits the ClinicalTrials.gov site

Publications:

Centers for Disease Control and Prevention (CDC). Chlamydia trachomatis genital infections--United States, 1995. MMWR Morb Mortal Wkly Rep. 1997 Mar 7;46(9):193-8.

Dean D, Suchland RJ, Stamm WE. Evidence for long-term cervical persistence of Chlamydia trachomatis by omp1 genotyping. J Infect Dis. 2000 Sep;182(3):909-16. Epub 2000 Aug 17.

Jones RB, Rabinovitch RA, Katz BP, Batteiger BE, Quinn TS, Terho P, Lapworth MA. Chlamydia trachomatis in the pharynx and rectum of heterosexual patients at risk for genital infection. Ann Intern Med. 1985 Jun;102(6):757-62.

Cotter TW, Ramsey KH, Miranpuri GS, Poulsen CE, Byrne GI. Dissemination of Chlamydia trachomatis chronic genital tract infection in gamma interferon gene knockout mice. Infect Immun. 1997 Jun;65(6):2145-52.

Igietseme JU, Portis JL, Perry LL. Inflammation and clearance of Chlamydia trachomatis in enteric and nonenteric mucosae. Infect Immun. 2001 Mar;69(3):1832-40.

Responsible Party:	Arkansas Children's Hospital Research Institute ( Amy Scurlock, MD )
Study ID Numbers:	IRB # 43921, ACH GL #039005
First Received:	December 19, 2007
Last Updated:	June 13, 2008
ClinicalTrials.gov Identifier:	NCT00578188
Health Authority:	United States: Federal Government

Keywords provided by Arkansas Children's Hospital Research Institute:

Adolescent Health

Sexually transmitted infection

Women's Health

Study placed in the following topic categories:

Genital Diseases, Female

Bacterial Infections

Sexually Transmitted Diseases

Chlamydia Infections

Genital Diseases, Male

Gram-Negative Bacterial Infections

Additional relevant MeSH terms:

Sexually Transmitted Diseases, Bacterial

Chlamydiaceae Infections

Infection

ClinicalTrials.gov processed this record on October 10, 2008