• Evolution to more severe forms of the disease [ Time Frame: 28-days follow up ] [ Designated as safety issue: No ]
  

• 28 days all-cause mortality,hyperglycemia, hypoglycemia, mean dose of insulin, use of hospital resources, ICU-free days,creatinine clearance, development of new organ failure,Evolution of the SOFA [ Time Frame: 28-days follow up ] [ Designated as safety issue: No ]
  

Inclusion Criteria:

• Patients over 18 years of age, at the intensive care unit with diagnosis of sepsis and requiring enteral nutrition. The diagnosis of sepsis follow the criteria previously defined by Bone et al., [40] and modified in accordance with Bernard GR et al. [30]. Included patients MUST start enteral feeding within 12 hours after fulfillment of all inclusion criteria to be considered evaluable. In adition, patients MUST achieve at least once 75% of BEE (calculated using the Harris-Benedict equation) x 1.3 to be considered evaluable. Patient septic state and caloric intake will be accessed in a daily basis.

Exclusion Criteria:

• Patients with septic shock at the baseline, pregnancy or breastfeeding, patients under 18 years of age, significant limitation of survival prognosis (patients expecting a life survival under 28 days due to a chronic and/or incurable disease such as uncontrolled cancer or other terminal disease), pre-existing chronic renal insufficiency and need of hemodyalisis or peritoneal dialysis, acute pancreatitis without established origin, participation in other clinical trial less than 30 days before inclusion in this trial, head trauma with a Glasgow Come Score (GCS) less or equal to 5, recent stroke or subarachnoid hemorrhage (less than 3 months), severe immunologic suppression (defined as a leukocyte count bellow 5.000 cells/mm3), infection by the human immunodeficiency virus, patients with no indication for enteral feeding or in the imminence of receiving parenteral nutrition, patients receiving partial parenteral nutrition in order to achieve caloric goal, presence of uncontrolled diarrhea, recent gastrointestinal bleeding event, or patient's, patient's legal representative or physicians decision to exclude patients from this protocol, known hypertriglyceridemia, obesity with BMI over 29.9.