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| Sponsored by: |
National Cancer Institute (NCI) |
| Information provided by: | National Cancer Institute (NCI) |
| ClinicalTrials.gov Identifier: | NCT00516568 |
Purpose
RATIONALE: Exposure to low-level benzene in the work place may affect the risk of developing cancer later in life. Learning about the long-term effects of benzene exposure may help the study of cancer and related disorders in the future.
PURPOSE: This clinical trial is studying benzene exposure as a risk factor for hematological cancer or related disorders or lung cancer in Chinese workers.
| Condition | Intervention |
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Leukemia Lung Cancer Lymphoma Multiple Myeloma and Plasma Cell Neoplasm Myelodysplastic Syndromes Myelodysplastic/Myeloproliferative Diseases |
Procedure: laboratory biomarker analysis Procedure: polymorphism analysis Procedure: questionnaire administration |
| Genetics Home Reference related topics: | aceruloplasminemia hemophilia |
| MedlinePlus related topics: | Cancer Leukemia, Adult Acute Leukemia, Adult Chronic Lung Cancer Lymphoma Multiple Myeloma |
| ChemIDplus related topics: | Salicylsalicylic acid Sodium salicylate |
| Study Type: | Observational |
| Official Title: | A Case-Cohort Study of Hematopoietic Malignancies and Related Disorders and Lung Cancer in Benzene-Exposed Workers in China |
| Estimated Enrollment: | 3860 |
OBJECTIVES:
OUTLINE: Participants complete questionnaires to collect information on potential confounders to the analysis of benzene's effects and information on work experience outside of the study cohort factories.
Patients undergo buccal cell and blood sample collection periodically for biological studies. Samples are analyzed for genetic polymorphisms potentially associated with benzene metabolism and disease status via polymorphism analysis.
Eligibility
| Ages Eligible for Study: | 18 Years and older |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
DISEASE CHARACTERISTICS:
Meets 1 of the following criteria:
Worker exposed to benzene
PATIENT CHARACTERISTICS:
PRIOR CONCURRENT THERAPY:
Contacts and Locations More Information
Clinical trial summary from the National Cancer Institute's PDQ® database
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| Study ID Numbers: | CDR0000551706, NCI-06-C-N205 |
| First Received: | August 14, 2007 |
| Last Updated: | July 23, 2008 |
| ClinicalTrials.gov Identifier: | NCT00516568 |
| Health Authority: | Unspecified |
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