Relationship of Peritoneal Solute Transport Rate With VEGF in Children Undergoing Peritoneal Dialysis - Full Text View

Relationship of Peritoneal Solute Transport Rate With VEGF in Children Undergoing Peritoneal Dialysis

This study is currently recruiting participants.
Verified by Samsung Medical Center, December 2006

Sponsored by:	Samsung Medical Center
Information provided by:	Samsung Medical Center
ClinicalTrials.gov Identifier:	NCT00516061

Purpose

Vascular endothelial growth factor(VEGF) appears to play a central role in the process leading to peritoneal angiogenesis and increased level of VEGF may contribute to high peritoneal small-solute transport rate (PSTR) in continuous ambulatory peritoneal dialysis (CAPD) patients in adult. In children, lymphatic absorption of solute is greater than adult. VEGF-C is related to lymphogenesis, but its role in peritoneal solute transport rate is not known. In this study, we evaluated possible relationship between dialysate VEGF and VEGF-C levels and PSTR in children.

Condition

Peritoneal Dialysis

MedlinePlus related topics:

Kidney Failure

U.S. FDA Resources

Study Type:	Observational
Study Design:	Natural History, Cross-Sectional, Defined Population, Retrospective/Prospective Study

Further study details as provided by Samsung Medical Center:

Estimated Enrollment:	40
Study Start Date:	December 2006
Estimated Study Completion Date:	December 2007

Detailed Description:

There was significant correlation between dialysate VEGF165 and VEGF-C levels and significant correlation was noted between dialysate VEGF165 and PSTR. Interestingly, dialysate VEGF-C levels had significant correlation with PSTR. High PSTR seems to be related to elevated VEGF-C and VEGF.

Eligibility

Ages Eligible for Study:	1 Year to 18 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes

Criteria

Inclusion Criteria:

chronic renal failure
children
peritoneal dialysis

Exclusion Criteria:

acute illness

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00516061

Contacts


Contact: Kyung Hoon Paik, M.D.	82-2-3410-1284	drwhite@skku.edu

Locations


Korea, Republic of
	Samsung Medical Center	Recruiting
	Seoul, Korea, Republic of, 135-710
	Contact: Kyung Hoon Paik, M.D. 82-2-3410-1284 drwhite@skku.edu

Sponsors and Collaborators

Samsung Medical Center

Investigators


Principal Investigator:	Kyung Hoon Paik, M.D.	Samsung Medical Center, Sungkyunkwan University School of Medicine

More Information

Study ID Numbers:	2006-12-008
First Received:	August 13, 2007
Last Updated:	August 13, 2007
ClinicalTrials.gov Identifier:	NCT00516061
Health Authority:	South Korea: Institutional Review Board

ClinicalTrials.gov processed this record on October 07, 2008