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Sponsors and Collaborators: |
University of California, San Francisco National Institute of Neurological Disorders and Stroke (NINDS) |
Information provided by: | National Institute of Neurological Disorders and Stroke (NINDS) |
ClinicalTrials.gov Identifier: | NCT00552045 |
The purpose of this study is to collect detailed information about the characteristics and genetics of a large number of individuals with epilepsy.
Condition |
Epilepsy Localization-Related Epilepsy Infantile Spasms Lennox-Gastaut Syndrome |
Genetics Home Reference related topics: | autosomal dominant partial epilepsy with auditory features pyridoxal 5'-phosphate-dependent epilepsy |
MedlinePlus related topics: | Epilepsy |
Study Type: | Observational |
Study Design: | Case Control, Prospective |
Official Title: | Epilepsy Phenome/Genome Project: A Phenotype/Genotype Analysis of Epilepsy |
whole blood
Estimated Enrollment: | 6750 |
Study Start Date: | November 2007 |
Estimated Study Completion Date: | November 2011 |
Estimated Primary Completion Date: | November 2011 (Final data collection date for primary outcome measure) |
Groups/Cohorts |
subject
individuals with epilepsy
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control
individuals without epilepsy
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Epilepsy is one of the most common neurological disorders and is a major public health concern. Approximately 30 percent of people with epilepsy have medically intractable epilepsy, and the medical and social consequences of the disorder are enormous. Treatments developed for epilepsy have largely been experimental rather than based on knowledge of basic mechanisms because the mechanisms are poorly understood.
The Epilepsy Phenome/Genome Project (EPGP) is a large-scale, national, multi-institutional, collaborative research project aimed at advancing the understanding of the genetic basis of the most common forms of epilepsy.
The overall goal of EPGP is to collect detailed, high quality phenotypic (i.e., characteristics of individuals, from the molecular level to the whole person) information on persons with epilepsy and controls (persons without epilepsy), and to compare the phenotypic information with genomic information. EPGP will provide a national resource that may lead to many discoveries related to the diagnosis and treatment of epilepsy, including the eventual development of new therapies based on a better understanding of causes of the disorder.
Ages Eligible for Study: | up to 60 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Non-Probability Sample |
EPGP will recruit persons with specific forms of epilepsy and controls without epilepsy.
Inclusion Criteria:
Subjects:
High quality clinical and laboratory data (i.e., neuroimaging, EEG) must be available throughout the patient's history:
Controls
Exclusion Criteria:
Subjects:
Controls:
Contact: Kristen Schardein | 415-476-4495 | kristen.schardein@ucsf.edu |
Contact: Kristen Schardein--toll free | 1-888-279-EPGP |
United States, Alabama | |||||
University of Alabama at Birmingham, Epilepsy Center, 1719 6th Ave S, CIRC, Ste 312 | Recruiting | ||||
Birmingham, Alabama, United States, 35294 | |||||
Contact: Robert Knowlton, M.D. 205-934-3866 knowlton@uab.edu | |||||
United States, California | |||||
University of California, San Francisco, 400 Parnassus, Room 847 | Recruiting | ||||
San Francisco, California, United States, 94143-0114 | |||||
Contact: Daniel Lowenstein, M.D. 415-502-2365 lowenstein@medsch.ucsf.edu | |||||
United States, Georgia | |||||
Emory School of Medicine, 1365 Clifton Road NE, Suite A3446 | Recruiting | ||||
Atlanta, Georgia, United States, 30322 | |||||
Contact: Sandra L Helmers, M.D. 404-778-5943 Sandra_helmers@emoryhealthcare.org | |||||
United States, Illinois | |||||
Rush Presbyterian St. Luke's Medical Center, 1653 West Congress Parkway | Recruiting | ||||
Chicago, Illinois, United States, 60612-3833 | |||||
Contact: Michael Smith, M.D. 312-942-5939 msmith@rush.edu | |||||
United States, Maryland | |||||
Johns Hopkins University, Meyer 2-147, 600 North Wolfe Street | Recruiting | ||||
Baltimore, Maryland, United States, 21287-0001 | |||||
Contact: Eileen G Vining, M.D. 410-955-9100 evining@jhmi.edu | |||||
United States, Michigan | |||||
University of Michigan Medical Center, Department of Neurology, 5021 BSRB, 109 Zina Pitcher Place | Recruiting | ||||
Ann Arbor, Michigan, United States, 48109-2200 | |||||
Contact: Lawrence Hudson, M.D. 734-936-7310 hudslawr@med.umich.edu | |||||
United States, Minnesota | |||||
Mayo Clinic College of Medicine, 200 First St., SW | Recruiting | ||||
Rochester, Minnesota, United States, 55905 | |||||
Contact: Gregory Cascino, M.D. gcascino@mayo.edu | |||||
United States, New Jersey | |||||
Saint Barnabas Medical Center, Institute of Neurology, 101 Old Short Hills Road, 4th Floor, Suite #415 | Recruiting | ||||
West Orange, New Jersey, United States, 07052 | |||||
Contact: Eric Geller, M.D. 973-322-6227 egeller@sbhcs.com | |||||
United States, New York | |||||
Albert Einstein College of Medicine, 111 East 210th St. | Recruiting | ||||
Bronx, New York, United States, 10467 | |||||
Contact: Sheryl Haut, M.D. 718-920-4378 haut@aecom.yu.edu | |||||
Gertrude H. Sergievsky Center, Columbia University, 630 West 168th Street, P&S Box 16 (no patient enrollment) | Active, not recruiting | ||||
New York, New York, United States, 10032 | |||||
Comprehensive Epilepsy Center, NYU Medical Center, 403 E. 34th Street, 4th Floor | Recruiting | ||||
New York, New York, United States, 10016 | |||||
Contact: Orrin Devinsky, M.D. 212-263-8870 od4@nyu.edu | |||||
United States, Ohio | |||||
Children's Hospital Medical Center, 3333 Burnet Avenue | Recruiting | ||||
Cincinnati, Ohio, United States, 45229-3026 | |||||
Contact: Tracy Glauser, M.D. 513-636-4222 tracy.glauser@cchmc.org | |||||
United States, Pennsylvania | |||||
Children's Hospital of Philadelphia, 34th and Civic Center Blvd., 6th Floor Wood Bldg—Neurology | Recruiting | ||||
Philadelphia, Pennsylvania, United States, 19104 | |||||
Contact: Dennis Dlugos, M.D. 215-590-1719 dlugos@email.chop.edu | |||||
United States, Texas | |||||
Baylor College of Medicine, One Baylor Plaza | Recruiting | ||||
Houston, Texas, United States, 77030-3411 | |||||
Contact: Eli Mizrahi, M.D. 713-790-3109 emizrahi@bcm.tmc.edu |
University of California, San Francisco |
National Institute of Neurological Disorders and Stroke (NINDS) |
Principal Investigator: | Daniel Lowenstein, MD | University of California, San Francisco, Department of Neurology |
Principal Investigator: | Ruben Kuzniecky, MD | New York University, Comprehensive Epilepsy Center |
EPGP website 
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Responsible Party: | University of California, San Francisco, Department of Neurology ( Daniel Lowenstein, MD, Professor of Neurology and Director, Physician-Scientist Education and Training Programs ) |
Study ID Numbers: | 1R01NS053998-01A1, CRC |
First Received: | October 30, 2007 |
Last Updated: | August 18, 2008 |
ClinicalTrials.gov Identifier: | NCT00552045 |
Health Authority: | United States: Federal Government |
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