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Sponsored by: |
Stanford University |
Information provided by: | Stanford University |
ClinicalTrials.gov Identifier: | NCT00318864 |
The purpose of this study is to determine if improvements in mood will ameliorate autonomic dysregulation, HPA dysfunction and typical (e.g. lipids) and atypical risk factors in depressed patients with elevated cardiovascular risk (CVD). Up to 70, depressed participants with elevated cardiovascular risk factors were randomized to a cognitive behavioral intervention (CBT) or a waiting list control (WLC) condition. Twenty non-depressed age and risk-matched controls will also recruited. Traditional risk factors (e.g. lipids, blood pressure, heart rate), atypical risk factors (endothelial function, asymmetric dimethylarginine, C-reactive protein) will be measured pre and post treatment six months later Subjects will undergo a psychophysiological stress test while cardiovascular physiology was measured. Salivary cortisol will be measured during the day and during the psychological stress test. Depressed subjects will be randomized to a 16 week cognitive behavior therapy intervention or to a wait-list control. It is hypothesized that reduction in mood will be associated with reduction in typical and atypical risk factors.
Condition | Intervention |
Depression Hypertension Hypercholesterolemia |
Behavioral: Cognitive behavioral therapy |
Genetics Home Reference related topics: | hypercholesterolemia |
MedlinePlus related topics: | Cholesterol Depression High Blood Pressure Stress |
Study Type: | Interventional |
Study Design: | Treatment, Randomized, Double-Blind, Active Control, Single Group Assignment, Bio-equivalence Study |
Official Title: | Stress, the HPA and Health in Aging |
Estimated Enrollment: | 70 |
Study Start Date: | June 2002 |
Estimated Study Completion Date: | July 2005 |
Show Detailed Description |
Ages Eligible for Study: | 55 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
United States, California | |||||
Stanford Medical Center | |||||
Stanford, California, United States, 94305 |
Stanford University |
Principal Investigator: | Craig B Taylor | Stanford Medical Center |
Study ID Numbers: | CBarrTaylor, 5 p01 AG18784-02 |
First Received: | April 25, 2006 |
Last Updated: | April 25, 2006 |
ClinicalTrials.gov Identifier: | NCT00318864 |
Health Authority: | United States: Institutional Review Board |
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