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Sponsors and Collaborators: |
Trillium Health Centre Toshiba Medical Systems |
Information provided by: | Trillium Health Centre |
ClinicalTrials.gov Identifier: | NCT00259493 |
The purpose of this study is to compare graft patency rates following coronary artery bypass graft surgery performed by beating heart vs. conventional techniques using cardiac CT scanning to evaluate the bypass grafts.
Condition | Intervention |
Coronary Artery Disease Amenable to Bypass Graft Surgery |
Procedure: Off-Pump Coronary Artery Bypass Graft Surgery |
MedlinePlus related topics: | Coronary Artery Bypass Surgery Coronary Artery Disease |
Study Type: | Interventional |
Study Design: | Treatment, Randomized, Double-Blind, Active Control, Single Group Assignment, Efficacy Study |
Official Title: | Graft Patency Following Off-Pump CABG Vs. On-Pump CABG Using 64 MDCT Bypass Graft CT Angiography |
Estimated Enrollment: | 350 |
Study Start Date: | December 2005 |
Estimated Study Completion Date: | October 2007 |
The issue of whether to perform conventional CABG or off-pump CABG continues to be the subject of debate. Controversy remains regarding the appropriateness of applying OPCAB to all patients as opposed to selected sub-populations.
The main strategy of CABG is to obtain complete revascularization with the least morbidity and highest long-term patency rates. Current medical literature is conflicted regarding graft patency rates in OPCAB vs. conventional CABG. Data is also limited due to patient refusal for conventional angiography to assess grafts following surgery. Cardiac computed tomography (CT) offers a non-invasive method to assess graft patency that is 100% accurate for the diagnosis of graft patency vs. occlusion. This study is a prospective randomized controlled trial evaluating graft patency in on-pump vs. off-pump CABG using cardiac CT scanning. The study hypothesis is that graft patency rates will be equivalent between the two techniques.
Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Contact: Kathy Ariss, BSc, RN | 416-400-4753 | kariss@thc.on.ca |
Canada, Ontario | |||||
Trillium Health Centre | Recruiting | ||||
Mississauga, Ontario, Canada, L5B 1B8 |
Trillium Health Centre |
Toshiba Medical Systems |
Principal Investigator: | Tarang N Sheth, MD, FRCPC | Trillium Health Centre |
Principal Investigator: | Gopal Bhatnagar, MD, FRCSC | Trillium Health Centre |
Study ID Numbers: | 001 |
First Received: | November 25, 2005 |
Last Updated: | September 7, 2006 |
ClinicalTrials.gov Identifier: | NCT00259493 |
Health Authority: | Canada: Ethics Review Committee |
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