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Sponsors and Collaborators: |
University of Copenhagen EC-FP6 (contract number: LHM-CT-2003-503041) Aditech Pharma AB |
Information provided by: | University of Copenhagen |
ClinicalTrials.gov Identifier: | NCT00259246 |
The aim of the study is to compare fasting and postprandial PYY levels between overweight/obese and lean subjects during and after an infusion of saline, PYY1-36 or PYY3-36 and to evaluate the efects on appetite, energy intake and energy expenditure.
Condition | Intervention |
Obesity |
Drug: Peptide YY infusion |
MedlinePlus related topics: | Obesity |
ChemIDplus related topics: | Sodium chloride Peptide YY |
Study Type: | Interventional |
Study Design: | Treatment, Randomized, Single Blind, Placebo Control, Crossover Assignment, Efficacy Study |
Official Title: | Fasting and Postprandial Response After Infusion of Saline, PYY1-36 and PYY3-36 and Effects on Appetite, Energy Intake and Energy Expenditure in Overweight/Obese Compared to Normalweight Subjects |
Estimated Enrollment: | 24 |
Study Start Date: | June 2004 |
Estimated Study Completion Date: | November 2005 |
The study is a randomised dobbelblinded placebo controlled study with 24 male subjects ( 12 lean and 12 overweight/obese subjects). VAS scores are used to assess appetite and two ad libitum meals are served in the hours following the infusion. Energy expenditure is measured by ventilated hood system and blood is sampled during part of the study day.
Ages Eligible for Study: | 20 Years to 50 Years |
Genders Eligible for Study: | Male |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
Study ID Numbers: | B208,1 |
First Received: | November 25, 2005 |
Last Updated: | May 30, 2006 |
ClinicalTrials.gov Identifier: | NCT00259246 |
Health Authority: | Denmark: The Danish National Committee on Biomedical Research Ethics |
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