Genetic Study of Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS) - Full Text View

Purpose

Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS) is a common condition with no known cure. It is estimated that every 15 seconds, a man in the USA is diagnosed with CP/CPPS. Studies have suggested that the condition may be genetic and passed down (or inherited) from one generation to the next.

In this study we are comparing different families' samples and medical information to determine which genetic factors may play a role in CP/CPPS. We will be collecting DNA and urine from each participant. Individuals and families with CP/CPPS will be enrolled. Family members are eligible with or without CP/CPPS symptoms

Condition

Chronic Prostatitis (CP)
Chronic Pelvic Pain Syndrome (CPPS)
Painful Bladder Syndrome (PBS)
Benign Frequency Syndrome (BFS)
Benign Daytime Frequency Syndrome (BDFS)

MedlinePlus related topics:

Pelvic Pain

U.S. FDA Resources

Study Type:	Observational
Study Design:	Family-Based, Prospective

Further study details as provided by Children's Hospital Boston:

Biospecimen Retention: Samples With DNA

Biospecimen Description:

DNA sample via saliva and urine samples will be collected and stored.

Estimated Enrollment:	500
Study Start Date:	January 2007
Estimated Study Completion Date:	January 2011

Detailed Description:

To further describe the phenotype of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) and to correlate the phenotypic information with the genotypic findings utilizing linkage analysis and candidate gene studies. A North American cohort and a Bulgarian cohort will be recruited. Each individual participant will be required to give a DNA sample (via Saliva) and a urine sample. All samples will be stored.

Eligibility

Ages Eligible for Study:	8 Years and older
Genders Eligible for Study:	Male
Accepts Healthy Volunteers:	Yes
Sampling Method:	Non-Probability Sample

Study Population

We are collecting individuals and families with symptoms and diagnoses of CP/CPPS and their family members (with or without symptoms) from North America (United States and Canada)

Criteria

Inclusion Criteria:

Have symptoms for at least 3 months within the preceding 6 months:
Pain in the pelvic area
Urinary frequency and/or
Urinary urgency and/or
Sexual dysfunction (erectile dysfunction)
Have CP/CPPS, IC, PBS, or BFS
Be willing to provide a saliva and urine sample
Agree to complete several brief questionnaires
Family member of someone with CP/CPPS, PBS, IC or BFS
Live in the USA or Canada

Exclusion Criteria:

Major structural/anatomical urinary tract abnormalities
Underlying inborn or congenital conditions which affect the urinary tract

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00499317

Contacts


Contact: Elicia Estrella, MS	617-919-4552	elicia.estrella@childrens.harvard.edu

Contact: Stephanie J. Brewster, MS	617-919-4551	stephanie.brewster@childrens.harvard.edu

Locations


United States, Massachusetts
	Children's Hospital, Boston	Recruiting
	Boston, Massachusetts, United States, 02115
	Principal Investigator: Jordan Dimitrakov, MD, PhD

Sponsors and Collaborators

Children's Hospital Boston

Investigators


Principal Investigator:	Jordan Dimitrakov, MD, PhD	Children's Hospital Boston

More Information

Publications of Results:

Dimitrakov JD. A case of familial clustering of interstitial cystitis and chronic pelvic pain syndrome. Urology. 2001 Aug;58(2):281.

Other Publications:

Dimitrakov JD, Kaplan SA, Kroenke K, Jackson JL, Freeman MR. Management of chronic prostatitis/chronic pelvic pain syndrome: an evidence-based approach. Urology. 2006 May;67(5):881-8. Review. No abstract available.

Propert KJ, Alexander RB, Nickel JC, Kusek JW, Litwin MS, Landis JR, Nyberg LM, Schaeffer AJ; Chronic Prostatitis Collaborative Research Network. Design of a multicenter randomized clinical trial for chronic prostatitis/chronic pelvic pain syndrome. Urology. 2002 Jun;59(6):870-6.

Responsible Party:	Children's Hospital, Boston ( Jordan Dimitrakov, M.D., Ph.D. )
Study ID Numbers:	04-11-160M
First Received:	July 9, 2007
Last Updated:	May 22, 2008
ClinicalTrials.gov Identifier:	NCT00499317
Health Authority:	United States: Institutional Review Board

Keywords provided by Children's Hospital Boston:

Urgency

Frequency

Pelvic pain

Sexual dysfunction

Erectile dysfunction

Study placed in the following topic categories:

Prostatitis

Signs and Symptoms

Cystitis, Interstitial

Pelvic Pain

Urologic Diseases

Prostatic Diseases

Urinary Bladder Diseases

Cystitis

Chronic Disease

Pain

Genital Diseases, Male

Erectile Dysfunction

Additional relevant MeSH terms:

Disease Attributes

Pathologic Processes

Disease

Syndrome

ClinicalTrials.gov processed this record on October 06, 2008

Sponsored by:	Children's Hospital Boston
Information provided by:	Children's Hospital Boston
ClinicalTrials.gov Identifier:	NCT00499317