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Sponsored by: |
North Suffolk Mental Health Association |
Information provided by: | North Suffolk Mental Health Association |
ClinicalTrials.gov Identifier: | NCT00499044 |
The investigators will compare the test-retest reliabilities of two cognitive batteries in people with schizophrenia: Cognitive Drug Research Computerized Cognitive Assessment System ("CDR") and MATRICS Consensus Cognitive Battery ("MCCB"). The investigators hypothesize that there will be a statistically significant difference in the test-retest reliabilities between MCCB and CDR. In addition, the investigators hypothesize that each of the two batteries will better measure certain areas of cognition. The investigators also hypothesize that scores from both batteries will correlate with quality of life scores, and that there will be a significant difference between the correlations of MCCB and CDR. The investigators hypothesize there will be a significant difference in patients' self-reported tolerability and satisfaction of the MATRICS versus CDR assessments. Lastly, the investigators hypothesize that there will be a significant difference in the MATRICS versus CDR batteries with respect to an administrator-rated score of practicality.
Approximately 32 subjects will enroll in the study. Following consent and eligibility screening (visit 1) and baseline clinical assessment and training in the use of the CDR battery (visit 2), subjects will be randomized into one of two groups for visits 3 and 4. One group will complete the CDR and then MCCB in visit 3, as well as the Tolerability Scale for each battery. The other group will complete the batteries in reverse order during visit 3. Each group will complete both batteries again in reverse order for visit 4. Randomization will be done in blocks of 2. After completion of every 4 subjects, study administrators will complete the Practicality Scale for each battery.
Condition | Intervention |
Schizophrenia Schizoaffective Disorder |
Other: CDR Computerized Cognitive Assessment System Other: MATRICS Consensus Cognitive Battery |
MedlinePlus related topics: | Memory Schizophrenia |
Study Type: | Interventional |
Study Design: | Other, Randomized, Open Label, Crossover Assignment |
Official Title: | CDR Versus MATRICS Cognitive Batteries in Patients With Schizophrenia |
Estimated Enrollment: | 32 |
Study Start Date: | December 2007 |
Estimated Study Completion Date: | January 2009 |
Estimated Primary Completion Date: | January 2009 (Final data collection date for primary outcome measure) |
Arms | Assigned Interventions |
1: Experimental
MATRICS Consensus Cognitive Battery
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Other: MATRICS Consensus Cognitive Battery
The MATRICS Consensus Cognitive Battery measures functioning across various cognitive domains, such as attention, working memory (verbal and nonverbal), learning (verbal and visual), reasoning and problem solving, and social cognition. Its measurements are based on timed paper-and-pencil, computerized, and orally-administered tests, as well as spatial tests using geometric cubes.
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2: Experimental
Cognitive Drug Research Computerized Cognitive Assessment System
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Other: CDR Computerized Cognitive Assessment System
Cognitive Drug Research Computerized Cognitive Assessment System consists of performance tasks that measure reaction time, numeric and spatial working memory, word and picture recall and recognition, and episodic secondary memory. CDR is a single, unified battery that can be stored and administered using a laptop computer.
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Show Detailed Description |
Ages Eligible for Study: | 18 Years to 65 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Contact: Priscilla Sinclair, B.A. | (617) 912-7886 | psinclair1@partners.org |
Contact: Alice Coakley, B.A. | (617) 912-7863 | acoakley1@partners.org |
United States, Massachusetts | |||||
Freedom Trail Clinic, Massachusetts General Hospital | Recruiting | ||||
Boston, Massachusetts, United States, 02114 | |||||
Contact: Priscilla Sinclair, B.A. 617-912-7886 psinclair1@partners.org | |||||
Contact: Alice Coakley, B.A. (617) 912-7863 acoakley1@partners.org | |||||
Principal Investigator: A. Eden Evins, M.D., M.P.H. |
North Suffolk Mental Health Association |
Principal Investigator: | A. Eden Evins, M.D., M.P.H. | Massachusetts General Hospital |
CDR Computerized Assessment System 
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Measurement and Treatment Research to Improve Cognition in Schizophrenia 
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Responsible Party: | Massachusetts General Hospital ( A. Eden Evins, M.D., M.P.H. ) |
Study ID Numbers: | CORRC #18-2007 |
First Received: | July 9, 2007 |
Last Updated: | September 29, 2008 |
ClinicalTrials.gov Identifier: | NCT00499044 |
Health Authority: | United States: Institutional Review Board |
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