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Sponsored by: |
Assaf-Harofeh Medical Center |
Information provided by: | Assaf-Harofeh Medical Center |
ClinicalTrials.gov Identifier: | NCT00498238 |
We evaluated the effect of levothyroxine in subclinical hypothyroidism (SCH) on arterial stiffness, lipid profile and inflammation. Thirty-four patients with SCH were included. Patients were treated with levothyroxine for 7 months. Arterial stiffness was evaluated by Augmentation index (AIx). After accomplishing euthyroidism, the AIx decreased from 8.3±17.2 to 6.5±14.3(P<0.01) and AIx percentage decreased from36.2 11.5 ± to 9.1±33.2 (P =0.03). Systolic blood pressure decreased from 20±134.7 to mmHg 13.7±127.6 (P<0.01). No significant improvement was found in other parameters. In patients whose AIx's decreased, LDL-cholesterol levels decreased by 37.1±-15.5 mg/dl compared to the patients whose AIx's didn't decrease and LDL-cholesterol increased by 57.4±24.1 mg/dl (P=0.057). We concluded that in patients suffering from SCH, treatment with levothyroxine had a significant beneficial effect on arterial stiffness and systolic blood pressure and no effect on lipid profile or inflammation.
Condition | Intervention |
Subclinical Hypothyroidism |
Drug: Levothyroxine |
ChemIDplus related topics: | Levothyroxine Sodium Thyroxine Lipids |
Study Type: | Interventional |
Study Design: | Open Label, Uncontrolled, Single Group Assignment |
Official Title: | The Effect of Levothyroxine on Arterial Stiffness and Lipid Profile in Patients |
Enrollment: | 34 |
Study Start Date: | July 2003 |
Study Completion Date: | September 2005 |
Show Detailed Description |
Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Assaf-Harofeh Medical Center |
Principal Investigator: | Ronit Koren, MD | Department of Internal Medicine A , Research & Development unit Assaf Harofeh Medical Center, Zerifin, affiliated to Sackler School of Medicine, |
Study ID Numbers: | ronit1 |
First Received: | July 6, 2007 |
Last Updated: | July 6, 2007 |
ClinicalTrials.gov Identifier: | NCT00498238 |
Health Authority: | Israel: Israeli Health Ministry Pharmaceutical Administration |
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