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Sponsored by: |
VISN3 Mental Illness Research, Education and Clinical Center |
Information provided by: | Bronx VA Medical Center |
ClinicalTrials.gov Identifier: | NCT00751855 |
This study seeks to examine the efficacy of hydrocortisone administration in the augmentation of the therapeutic effects of Prolonged Exposure (PE) therapy, an empirically tested treatment shown to be effective in the the treatment of posttraumatic stress disorder (PTSD). The augmentation builds on both the translation of neuroscience findings demonstrating the effects of glucocorticoids (GCs) on learning, and on empirical clinical findings from other investigators demonstrating beneficial effects of GCs in reducing traumatic memories in trauma-exposed persons.
Condition | Intervention |
PTSD |
Behavioral: Prolonged Exposure therapy Drug: Hydrocortisone Drug: placebo |
MedlinePlus related topics: | Memory |
Study Type: | Interventional |
Study Design: | Treatment, Randomized, Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Parallel Assignment, Efficacy Study |
Official Title: | Cortisol Augmentation of Prolonged Exposure Therapy |
Estimated Enrollment: | 16 |
Arms | Assigned Interventions |
1: Active Comparator
Prolonged Exposure therapy with Hydrocortisone
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Behavioral: Prolonged Exposure therapy
10 weekly sessions
Drug: Hydrocortisone
10mg 45 minutes prior to each PE session (10 total)
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2: Placebo Comparator
Prolonged Exposure therapy with placebo
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Behavioral: Prolonged Exposure therapy
10 weekly sessions
Drug: placebo
placebo
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Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Responsible Party: | James J. Peters VA Medical Center ( Rachel Yehuda ) |
Study ID Numbers: | YEH-08-044 |
First Received: | September 11, 2008 |
Last Updated: | September 11, 2008 |
ClinicalTrials.gov Identifier: | NCT00751855 |
Health Authority: | United States: Federal Government |
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