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| Sponsored by: |
University Hospital, Tours |
| Information provided by: | University Hospital, Tours |
| ClinicalTrials.gov Identifier: | NCT00750932 |
Purpose
The purpose of the proposed project is to characterize the neutrophile proteases which participate in the chronic inflammatory phenomenon associated with the cystic fibrosis and which are responsible for the degradation of the lung tissue.
The respiratory failure which results from it is one of main causes of the fatal evolution of this pathology but the anti-inflammatory therapies based on the use of antiproteases targeting specifically the soluble elastase did not end, until now, in the hoped results.
The identification of the other noxious targets is a crucial element to give new orientations to the anti-inflammatory strategies based on the administration of antiproteases which remain a promising way.
| Condition |
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Cystic Fibrosis |
| Genetics Home Reference related topics: | cystic fibrosis |
| MedlinePlus related topics: | Cystic Fibrosis |
| ChemIDplus related topics: | Serine Proteinase, serine |
| Study Type: | Observational |
| Study Design: | Case Control, Prospective |
| Official Title: | Study of the Biodistribution of PMN Serine Proteases in Sputum of Patients Affected by Cystic Fibrosis: Towards New Anti-Inflammatory Therapies |
Whole blood Sputum
| Estimated Enrollment: | 90 |
| Study Start Date: | January 2008 |
| Groups/Cohorts |
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T
Control
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M
Minor with cystic fibrosis
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A
Adult with cystic fibrosis
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Eligibility
| Ages Eligible for Study: | 6 Years and older |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
| Sampling Method: | Non-Probability Sample |
Adults and children with cystic fibrosis
Inclusion Criteria:
Exclusion Criteria:
Contacts and Locations| Contact: Patrice DIOT, PHD | +33247473787 | diot@med.univ-tours.fr |
| Contact: Pascaline RAMEAU | +33247474664 | rameau@med.univ-tours.fr |
| France | |||||
| CHRU de Tours | Recruiting | ||||
| TOURS, France, 37044 | |||||
| Contact: Patrice DIOT, PHD +33247473787 diot@med.univ-tours.fr | |||||
| Contact: Pascaline Rameau +33247474664 rameau@med.univ-tours.fr | |||||
| Principal Investigator: Patrice DIOT, PHD | |||||
| Sub-Investigator: Francoise Varaigne, MD | |||||
| Sub-Investigator: Charlotte GIRAUT, MD | |||||
| Sub-Investigator: Sophie MARCHAND, MD | |||||
| University Hospital, Tours |
| Principal Investigator: | Patrice DIOT, PHD | Tours Hospital |
| Principal Investigator: | Patrice DIOT, PHD | Tours Hospital |
More Information
| Responsible Party: | University Hospital, Tours ( University Hospital, Tours ) |
| Study ID Numbers: | AOHP07-PD Pro-Muco, DGS2007-0295, N° ID RCB:2007-A00511-52, CPP: 2007-R17 |
| First Received: | September 10, 2008 |
| Last Updated: | September 10, 2008 |
| ClinicalTrials.gov Identifier: | NCT00750932 |
| Health Authority: | France: Ministry of Health |
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