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| Sponsored by: |
University of California, San Francisco |
| Information provided by: | University of California, San Francisco |
| ClinicalTrials.gov Identifier: | NCT00750906 |
Purpose
This study will be conducted to determine the pharmacodynamics, cardiovascular and biochemical effects of succinylcholine when given during electroconvulsive therapy. (ECT). This is a single center, prospective, study in patients who will be receiving ECT as indicated and prescribed by their psychiatrist. The study will be performed twice on each patient, 48-72 hours apart during consecutively scheduled ECT procedures.
| Condition |
|
Depression |
| MedlinePlus related topics: | Depression |
| ChemIDplus related topics: | Potassium chloride Succinylcholine Succinylcholine chloride Suxamethonium bromide |
| Study Type: | Observational |
| Study Design: | Case-Only, Prospective |
| Official Title: | The Muscle Biochemical, Serum Potassium and Cardiovascular Changes After Succinylcholine in Patients Undergoing Electroconvulsive Therapy. |
| Estimated Enrollment: | 20 |
| Study Start Date: | September 2008 |
| Estimated Study Completion Date: | December 2009 |
| Estimated Primary Completion Date: | December 2009 (Final data collection date for primary outcome measure) |
Patients will receive the anesthetic that is traditionally given which includes appropriate doses of succinylcholine. Serum potassium and creatinine phosphokinase (CK) levels will be determined pre and post anesthesia; serum and urine myoglobin will be determined post anesthesia. Vital signs data [i.e., heart rate (arrhythmias) and arterial blood pressure] will be compared pre and post anesthesia. In addition patients will be asked about the presence of muscle pain (myalgia) 1 hour before discharge from the recovery room and the following day post ECT.
Eligibility
| Ages Eligible for Study: | 18 Years and older |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
| Sampling Method: | Non-Probability Sample |
Patients undergoing electroconvulsive therapy.
Inclusion Criteria:
Exclusion Criteria:
Contacts and Locations| Contact: Ronald D Miller, MD | (415) 476-9035 | millerr@anesthesia.ucsf.edu |
| Contact: Theresa A Ward, RN | (415) 514-0685 | wardt@anesthesia.ucsf.edu |
| United States, California | |||||
| University of California San Francisco | Not yet recruiting | ||||
| San Francisco, California, United States, 94143 | |||||
| Contact: Ronald D Miller, MD 415-476-9035 millerr@anesthesia. ucsf.edu | |||||
| Contact: Theresa A Ward, RN (415) 514-0685 wardt@anesthesia.ucsf.edu | |||||
| Principal Investigator: Matthias Braehler, MD | |||||
| Sub-Investigator: Ronald Miller, MD | |||||
| Sub-Investigator: Heiner Ruschulte, MD | |||||
| Sub-Investigator: Olga Afonin, MD | |||||
| Sub-Investigator: Theresa Ward, RN | |||||
| University of California, San Francisco |
| Study Director: | Ronald D Miller, MD | University of California, San Francisco |
More Information
| Responsible Party: | University of California San Francisco ( Matthias Braehler, MD ) |
| Study ID Numbers: | 08032701-01 |
| First Received: | September 9, 2008 |
| Last Updated: | September 9, 2008 |
| ClinicalTrials.gov Identifier: | NCT00750906 |
| Health Authority: | United States: Institutional Review Board |
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