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Sponsored by: |
National Institute on Alcohol Abuse and Alcoholism (NIAAA) |
Information provided by: | National Institute on Alcohol Abuse and Alcoholism (NIAAA) |
ClinicalTrials.gov Identifier: | NCT00330434 |
The two purposes of this study are
to determine what effect the chronic and moderate/heavy drinking of alcoholic beverages has
to determine what effect a normal and common (25% frequency) genetic variation of a specific liver enzyme (that breaks down bupropion) has
Two groups of volunteers will be recruited for this study:
Volunteers will NOT be asked to change their drinking (or nondrinking) habits during the study.
Condition | Intervention |
Alcohol Drinking Depression Smoking Cessation Attention Deficit Disorder |
Drug: Bupropion Drug: Chlorzoxazone Drug: Ethanol |
MedlinePlus related topics: | Alcohol Consumption Depression Smoking Smoking Cessation |
ChemIDplus related topics: | Bupropion hydrochloride Bupropion Ethanol Chlorzoxazone |
Study Type: | Interventional |
Study Design: | Treatment, Non-Randomized, Open Label, Placebo Control, Parallel Assignment, Pharmacodynamics Study |
Official Title: | Human CYP2B6: Induction by Ethanol and Polymorphisms |
Ages Eligible for Study: | 21 Years to 55 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
United States, Massachusetts | |||||
Tufts University School of Medicine | |||||
Boston, Massachusetts, United States, 02111 |
Principal Investigator: | David J. Greenblatt, MD | Tufts University; Chair of Department of Pharmacology and Experimental Therapeutics, Sackler School |
Principal Investigator: | Michael H. Court, BVsc, PhD | Tufts University, Department of Pharmacology and Experimental Therapeutics, Sackler School |
Study ID Numbers: | NIAAAGRE15647, 1 F32 AA15647-01A1 |
First Received: | May 25, 2006 |
Last Updated: | April 7, 2008 |
ClinicalTrials.gov Identifier: | NCT00330434 |
Health Authority: | United States: Federal Government |
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