Primary Outcome Measures:
- Efficacy Measured by the proportion of subjects who lose fewer than 15 letters in visual acuity at 6 and 12 month compared with baseline
- Safety and Tolerability as measured by the recording and observations of adverse effects of study treatment
Secondary Outcome Measures:
- Efficacy as measured by the mean change from baseline in VA at 6 and 12 months
- Efficacy as measured by the proportion of subjects who lose less than 5 letters of vision at month 6 and 12
- Efficacy as mean change from baseline at 6 to 12 months in decreasing subretinal hemorrhage or subretinal exudates via fundus photographs and fundus exams
- Efficacy as proportion of subjects with a decrease in size of the polypoidal vessels from PCV at Mo 6 and 12 as assessed by FA and ICG Angiography
- Efficacy as proportion of subjects with a decrease in macular edema as measured by OCT in central or paracentral fields from baseline month 6 and month 12.
Previous treatment in subjects is allowed as long as appropriate washout period has elapsed. Patients will be followed by 4M ETDRS vision testing as well as scheduled OCT, ICG, FA and Fundus Photography.