• Hawley C. Serum phosphate. Nephrology 2006 Apr;11(S1):S201-5.



• Hawley C. Serum phosphate. Westmead NSW (Australia): CARI - Caring for Australasians with Renal Impairment; 2005 Oct. 10 p. [21 references]

This is the current release of the guideline.

Definitions for the levels of evidence (I–IV) can be found at the end of the "Major Recommendations" field.

Guidelines

No recommendations possible based on Level I or II evidence

Suggestions for Clinical Care

(Suggestions are based on Level III and IV evidence)

General comments in relation to bone mineral metabolism:

• In Stage 5 kidney disease, serum phosphate, serum calcium, calcium x phosphate product and parathyroid hormone (PTH) level need to be considered simultaneously when assessing the bone mineral status of a patient: a combination of high calcium, high phosphate and low PTH level being associated with the worst outcome. (Level III evidence – cohort)
• Ideal targets for bone mineral metabolism parameters are unlikely to be met with conventional dialysis methods and available phosphate binders in the majority of patients. (Level III evidence - cohort)

Serum phosphate:

• In Stage 5 kidney disease, a predialysis serum phosphate level of 0.8 to 1.60 mmol/L is recommended as higher levels of serum phosphate have been shown to be associated with an increase in mortality. (Level III evidence – 8 cohort studies including 2 recent large studies with robust analyses and good quality, strong association, consistent effect seen).
• For Stages 3 and 4 kidney disease, serum phosphate should be kept within the normal laboratory reference range. (Opinion)
• It is unclear whether using high doses of phosphate binders, using the newer phosphate binders and/or whether performing longer dialysis to improve the bone mineral metabolism status of patients will translate into improvement in the mortality of patients with chronic kidney disease. (Opinion)
• For patients on haemodialysis, a fasting predialysis blood sample should be used. For other patients, a fasting blood sample should be used. (Level III evidence)

Definitions:

Levels of Evidence

Level I: Evidence obtained from a systematic review of all relevant randomized controlled trials (RCTs)

Level II: Evidence obtained from at least one properly designed RCT

Level III: Evidence obtained from well-designed pseudo-randomized controlled trials (alternate allocation or some other method); comparative studies with concurrent controls and allocation not randomized, cohort studies, case-control studies, interrupted time series with a control group; comparative studies with historical control, two or more single arm studies, interrupted time series without a parallel control group

Level IV: Evidence obtained from case series, either post-test or pretest/post-test

None provided

The type of supporting evidence is identified and graded for each recommendation (see "Major Recommendations").

• Hawley C. Serum phosphate. Nephrology 2006 Apr;11(S1):S201-5.



• Hawley C. Serum phosphate. Westmead NSW (Australia): CARI - Caring for Australasians with Renal Impairment; 2005 Oct. 10 p. [21 references]

Not applicable: The guideline was not adapted from another source.

2005 Oct

Caring for Australasians with Renal Impairment - Disease Specific Society

Industry-sponsored funding administered through Kidney Health Australia

Not stated

Author: Carmel Hawley

All guideline writers are required to fill out a declaration of conflict of interest.

This is the current release of the guideline.

None available

This NGC summary was completed by ECRI Institute on June 5, 2008. The information was verified by the guideline developer on June 11, 2008.

This NGC summary is based on the original guideline, which is subject to the guideline developer's copyright restrictions.