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Sponsored by: |
Hospices Civils de Lyon |
Information provided by: | Hospices Civils de Lyon |
ClinicalTrials.gov Identifier: | NCT00419198 |
We previously demonstrated that postconditioning by coronary angioplasty can decrease infarct size (as measured by cardiac enzyme release) in patients with ongoing acute myocardial infarction. It is currently unknown whether postconditioning actually decreases or simply delays myocardial cell death during reperfusion. In addition, the long term effects of postconditioning on recovery of myocardial contraction remains elusive. The objective of the present study is to determine whether infarct size reduction by angioplasty postconditioning is maintained at 6 months and whether functional recovery is improved at one year post-infarction.
Condition | Intervention |
Acute Myocardial Infarction |
Procedure: Postconditioning Procedure: standard angioplasty |
MedlinePlus related topics: | Angioplasty Heart Attack |
Study Type: | Interventional |
Study Design: | Diagnostic, Randomized, Open Label, Uncontrolled, Parallel Assignment, Efficacy Study |
Official Title: | Postconditioning and Functional Recovery After Acute Myocardial Infarction |
Enrollment: | 91 |
Study Start Date: | September 2005 |
Estimated Study Completion Date: | September 2008 |
Primary Completion Date: | March 2008 (Final data collection date for primary outcome measure) |
Arms | Assigned Interventions |
1: Experimental
Post-conditioning during angioplasty
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Procedure: Postconditioning
Postconditioning during angioplasty
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2: Active Comparator
standard angioplasty
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Procedure: standard angioplasty
standard angioplasty without postconditioning
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Randomized, controlled, single-blinded trial comparing postconditioning to control (no intervention). Postconditioning consists of four episodes of one minute inflation followed by one minute deflation of the angioplasty balloon, starting within one minute of reflow after direct stenting of the occluded coronary artery.
Ages Eligible for Study: | 18 Years to 90 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Responsible Party: | Hospices Civils de Lyon ( Michel Ovize, Pr. ) |
Study ID Numbers: | 2004.364 |
First Received: | January 5, 2007 |
Last Updated: | June 20, 2008 |
ClinicalTrials.gov Identifier: | NCT00419198 |
Health Authority: | France: Ministry of Health |
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