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Sponsors and Collaborators: |
National Institute of Child Health and Human Development (NICHD) National Institute on Drug Abuse (NIDA) National Institute of Mental Health (NIMH) National Institute on Alcohol Abuse and Alcoholism (NIAAA) |
Information provided by: | National Institute of Child Health and Human Development (NICHD) |
ClinicalTrials.gov Identifier: | NCT00107029 |
This protocol is a study of HIV+ young people who were identified as having certain HIV-1 specific T-cell responses and genetic markers while previously enrolled in the 5-year longitudinal adolescent study, "REACH." Blood samples will be collected, a medical and medication history and physical examination will be performed every 6 months for a total of 2 years.
Condition |
HIV Infection |
MedlinePlus related topics: | AIDS |
Study Type: | Observational |
Study Design: | Natural History, Longitudinal, Defined Population, Retrospective/Prospective Study |
Official Title: | Evaluation of HIV-Specific CD8+ T-Cell Responses and Escape Mutations as Explanations for the Observed Differences in Disease Progression Conferred by HLA Class I Alleles |
Estimated Enrollment: | 113 |
Study Start Date: | December 2002 |
Estimated Study Completion Date: | September 2005 |
Numerous studies have demonstrated an association between HLA class I genotypes with differing progression to AIDS in individuals who are followed after being off antiretroviral therapy. These studies do not always associate the same HLA class I alleles with the risks of HIV-1 disease progression; however they consistently demonstrated that HLA-B*35 and B*53 portend a bad outcome compared to the better outcome observed in HLA-B*27 and B*57 carriers. Despite this information, very little data exists to explain the mechanism of this association.
This longitudinal study will look at the HIV-1 specific CD8+ T-cell responses and the dominant HIV-1 genotype among individuals identified as HLA-B*27, B*35, B*53 and B*57 positive through studies done in collaboration with the REACH project.
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
United States, California | |||||
Children's Hospital of Los Angeles | |||||
Los Angeles, California, United States | |||||
United States, District of Columbia | |||||
Children's National Medical Center | |||||
Washington, District of Columbia, United States | |||||
United States, Florida | |||||
University of Miami-Jackson Memorial Medical Center | |||||
Miami, Florida, United States | |||||
Children's Diagnostic and Treatment Center | |||||
Ft. Lauderdale, Florida, United States | |||||
United States, Illinois | |||||
Cook County Children's Hospital | |||||
Chicago, Illinois, United States | |||||
United States, Louisiana | |||||
Tulane Medical Center | |||||
New Orleans, Louisiana, United States | |||||
United States, Maryland | |||||
University of Maryland | |||||
Baltimore, Maryland, United States | |||||
United States, New York | |||||
Children's Hospital at Montefiore Medical Center | |||||
Bronx, New York, United States | |||||
Mount Sinai Medical Center | |||||
New York, New York, United States | |||||
United States, Pennsylvania | |||||
Children's Hospital of Philadelphia | |||||
Philadelphia, Pennsylvania, United States |
Study Chair: | Paul Goepfert, MD | University of Alabama at Birmingham |
Website for the Adolescent Trials Network for HIV/AIDS Interventions 
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Study ID Numbers: | ATN 026 |
First Received: | April 4, 2005 |
Last Updated: | April 2, 2007 |
ClinicalTrials.gov Identifier: | NCT00107029 |
Health Authority: | United States: Federal Government |
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