• Safety & tolerability of the study regimen [ Time Frame: enrollment & treatment period 18 months ] [ Designated as safety issue: No ]
  
• Progression-free survival [ Time Frame: End of Study/Follow Up ] [ Designated as safety issue: No ]
  

• Percentage of patients with stable disease greater or equal to 16 weeks or CR or PR (disease control) [ Time Frame: End of Study ] [ Designated as safety issue: No ]
  
• Percentage of patients with objective confirmed complete or partial overall response (objective response) [ Time Frame: End of Study ] [ Designated as safety issue: No ]
  
• Patient survival [ Time Frame: End of Study ] [ Designated as safety issue: No ]
  
• Duration of response [ Time Frame: End of Study ] [ Designated as safety issue: No ]
  

Inclusion Criteria:

• Pathologically confirmed adenocarcinoma of the breast.
• Stage IV disease.
• Measurable disease (defined as the presence of at least one lesion that can be accurately measured in at least one dimension with longest diameter greater or = 1.0 cm with spiral CT scan).
• Patients must not be a candidate for Herceptin therapy (i.e., patients with HER-2 positive disease (gene amplification by FISH or 3 + overexpression by ICH and patients with unknown HER-2 status are ineligible unless the treating physicians has determined that Herceptin- based therapy would be inappropriate or not indicated.
• For subjects with prior anthracycline exposure, normal cardiac function including a baseline left ventricle ejection fraction >50% or above institution's lower limit of normal and a normal ECG (as assessed by the investigator).
• At least 2 weeks since radiotherapy, with full recovery. The measurable disease must be completely outside the radiation portal or there must be pathologic proof of progressive disease within the radiation portal.
• International Normalized Ratio(INR)< 1.5 and activated partial thromboplastin time within normal limits (APTT WNL).
• ECOG performance 0-2.
• Female > 18 years of age.
• Patients has the following blood counts at Baseline:ANC greater or equal to 1.5 x 10^9 cells/L; platelets greater or equal 100 x 10^9 cells/L; Hgb greater or equal to 9g/dL.
• Patients has the following blood chemistry levels at Baseline: AST (SGOT), ALT (SGPT)less than or equal 2.5x upper limit of normal (ULN) range (less than or equal 5x ULN if patient has known liver metastases); total bilirubin greater than or equal to ULN; creatinine greater or equal to 1.5mg/dL.
• if female of childbearing potential, pregnancy test is negative within 72 hours of first dose of study drug.
• if fertile, the patient agrees to use an effective method to avoid pregnancy for the duration of the study.
• Informed consent has been obtained.

Exclusion Criteria:

• No prior chemotherapy for metastatic or locally recurrent disease is allowed.

• Prio neo-adjuvant chemotherapy is allowed, and patients must have recovered from the acute toxicity of such therapies.

  • if a taxane was part of the adjuvant regimen, at least 12 months must have elapsed between the last dose of the taxane and the date of diagnosis of metastatic disease.
  • if a non-taxane-based adjuvant therapy was administered, at least six months must have elapsed between the last dose of the non- taxane-containing chemotherapy and the date of diagnosis of metastatic disease.
• Concurrent immunotherapy or hormonal therapy.
• Parenchymal brain metastases, including leptomeningeal involvement.
• Uncontrolled hypertension (defined as blood pressure of > 150/100 mmHg)
• NYHA Grade 2 or greater congestive heart failure
• History of coagulopathy, bleeding diathesis, therapeutic anticoagulation other than low dose or chronic ASA greater than or equal to 325 mg per day. Low dose coumadin for anticoagulation of venous access device or low dose molecular weight heparin (LMWH)for deep vein thrombosis prophylaxis or low dose (325 mg or less) ASA prophylaxis are allowed, but are best avoided if the treating physician feels it is safe to do so.
• Urine protein:creatinine ratio less than or equal to 1.0 at screening.
• No history of cerebrovascular accident within six months of study entry.
• Active symptomatic peripheral vascular disease(e.g. aortic aneurysm, claudication) within six months of study entry.
• Uncontrolled or severe cardiovascular disease including myocardial infarction or unstable angina within six months of study entry.
• No history of abdominal fistula, gastrointestinal perforation, or intra-abdominal process within six months of study entry.
• No serious non-healing wound, ulcer, or bone fracture
• Major surgical procedure, open biopsy, or significant traumatic injury within 28 days prior to first dose, or anticipation of need for major surgical procedure during the course of the study. No minor surgical procedure within seven days of study entry. Serious intercurrent medical or psychiatric illness, including serious active infection.
• History of other malignancy within the last 5 years which could affect the diagnosis or assessment of breast cancer.
• Current, recent (within 4 weeks of the first infusion of this study), or planned participation in an experimental drug study.
• Pregnant or nursing women.
• Patients with current sensory neuropathy of > Grade 1 will be excluded.