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Sponsors and Collaborators: |
Societe Internationale d'Oncologie Pediatrique Children's Cancer and Leukaemia Group Societe Francaise Oncologie Pediatrique |
Information provided by: | National Cancer Institute (NCI) |
ClinicalTrials.gov Identifier: | NCT00025441 |
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
PURPOSE: Phase II trial to study the effectiveness of combination chemotherapy in treating children with metastatic rhabdomyosarcoma or other malignant mesenchymal tumors.
Condition | Intervention | Phase |
Ovarian Cancer Sarcoma Small Intestine Cancer |
Drug: carboplatin Drug: cyclophosphamide Drug: dactinomycin Drug: doxorubicin hydrochloride Drug: epirubicin hydrochloride Drug: etoposide Drug: filgrastim Drug: ifosfamide Drug: vincristine sulfate Procedure: peripheral blood stem cell transplantation Procedure: radiation therapy |
Phase II |
MedlinePlus related topics: | Cancer Intestinal Cancer Ovarian Cancer Soft Tissue Sarcoma |
Study Type: | Interventional |
Study Design: | Treatment |
Official Title: | MMT 98 Study For Metastatic Disease Rhabdomyosarcoma And Other Malignant Soft Tissue Sarcoma Of Childhood |
Ages Eligible for Study: | 6 Years to 17 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
DISEASE CHARACTERISTICS:
Histologically confirmed metastatic rhabdomyosarcoma or other malignant mesenchymal tumors
Standard risk defined as:
High risk defined as:
PATIENT CHARACTERISTICS:
Age:
Performance status:
Life expectancy:
Hematopoietic:
Hepatic:
Renal:
PRIOR CONCURRENT THERAPY:
Biologic therapy:
Chemotherapy:
Endocrine therapy:
Radiotherapy:
Surgery:
France | |||||
Centre Leon Berard | |||||
Lyon, France, 69373 | |||||
Ireland | |||||
Our Lady's Hospital for Sick Children | |||||
Crumlin, Ireland, 12 | |||||
United Kingdom, England | |||||
Addenbrooke's Hospital at Cambridge University Hospitals NHS Foundation Trust | |||||
Cambridge, England, United Kingdom, CB2 2QQ | |||||
Birmingham Children's Hospital | |||||
Birmingham, England, United Kingdom, B4 6NH | |||||
Bristol Royal Hospital for Children | |||||
Bristol, England, United Kingdom, BS2 8BJ | |||||
Meyerstein Institute of Oncology at University College of London Hospitals | |||||
London, England, United Kingdom, WIT 3AA | |||||
Children's Hospital - Sheffield | |||||
Sheffield, England, United Kingdom, S10 2TH | |||||
Great Ormond Street Hospital for Children NHS Trust | |||||
London, England, United Kingdom, WC1N 3JH | |||||
Leeds Cancer Centre at St. James's University Hospital | |||||
London, England, United Kingdom, W6 8RF | |||||
Leicester Royal Infirmary | |||||
Leicester, England, United Kingdom, LE1 5WW | |||||
Central Manchester and Manchester Children's University Hospitals NHS Trust | |||||
Manchester, England, United Kingdom, M27 4HA | |||||
Newcastle Upon Tyne Hospitals NHS Trust | |||||
Newcastle-Upon-Tyne, England, United Kingdom, NE7 7DN | |||||
Oxford Radcliffe Hospital | |||||
Oxford, England, United Kingdom, 0X3 9DU | |||||
Queen's Medical Centre | |||||
Nottingham, England, United Kingdom, NG7 2UH | |||||
Royal Liverpool Children's Hospital, Alder Hey | |||||
Liverpool, England, United Kingdom, L12 2AP | |||||
Royal Marsden NHS Foundation Trust - Surrey | |||||
Sutton, England, United Kingdom, SM2 5PT | |||||
Saint Bartholomew's Hospital | |||||
London, England, United Kingdom, EC1A 7BE | |||||
Southampton General Hospital | |||||
Southampton, England, United Kingdom, SO16 6YD | |||||
United Kingdom, Northern Ireland | |||||
Royal Belfast Hospital for Sick Children | |||||
Belfast, Northern Ireland, United Kingdom, BT12 6BE | |||||
United Kingdom, Scotland | |||||
Aberdeen Royal Infirmary | |||||
Aberdeen, Scotland, United Kingdom, AB25 2ZN | |||||
Royal Hospital for Sick Children | |||||
Glasgow, Scotland, United Kingdom, G3 8SJ | |||||
Royal Hospital for Sick Children | |||||
Edinburgh, Scotland, United Kingdom |
Societe Internationale d'Oncologie Pediatrique |
Children's Cancer and Leukaemia Group |
Societe Francaise Oncologie Pediatrique |
Study Chair: | Heather P. McDowell, MD | Royal Liverpool Children's Hospital, Alder Hey |
Study Chair: | Annabel B.M. Foot | Bristol Royal Hospital for Children |
Study Chair: | Christophe Bergeron | Centre Leon Berard |
Clinical trial summary from the National Cancer Institute's PDQ® database 
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Study ID Numbers: | CDR0000068961, SIOP-MMT-98, SFOP-SIOP-MMT-98, CCLG-SIOP-MMT-98, EU-20126, STS-1998 |
First Received: | October 11, 2001 |
Last Updated: | August 23, 2008 |
ClinicalTrials.gov Identifier: | NCT00025441 |
Health Authority: | United States: Federal Government |
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