• Determine the overall response rate (RR) to bendamustine HCL in patients with relapsed and primary refractory HL. [ Time Frame: conclusion of study ] [ Designated as safety issue: No ]
  

• Determine rate of complete remission (CR) and partial remission (PR). [ Time Frame: conclusion of study ] [ Designated as safety issue: No ]
  
• Evaluate toxicity according to CTCAE v3.0 criteria. [ Time Frame: conclusion of study ] [ Designated as safety issue: Yes ]
  
• Determine progression free survival (PFS) and overall survival (OS) following treatment with bendamustine HCL in patients with relapsed and primary refractory HL. [ Time Frame: conclusion of study ] [ Designated as safety issue: No ]
  

Inclusion Criteria:

• Histologic diagnosis of Classical Hodgkin lymphoma, confirmed by the department of hematopathology at MSKCC.
• Age > or = to 18
• All patients must have PET avid measurable disease.
• Last chemotherapy > or = to 4 weeks from the start of Bendamustine HCl
• Receiving no other treatment for HL
• Patients must have normal baseline cardiac function based upon echocardiogram or gated blood pool scan (MUGA) with an ejection fraction > or = to 50%
• Patients must have a serum creatinine of < or = to 1.5 mg/dl; if creatinine >1.5 mg/dl creatinine clearance must be >60 ml/minute.
• Patients must have ANC>1000/mcl and Platelets>100,000/mcl.
• Patients must have a bilirubin level of < 2.0 mg/dl in the absence of a history of Gilbert's disease (or pattern consistent with Gilbert's).
• Patients must be Hepatitis B surface antigen and Hepatitis BE antigen negative and Hepatitis C negative.
• Patients must have failed an autologous stem cell transplant or be ineligible for an autologous stem cell transplant due to chemo-refractory disease(as defined as <50% response to standard salvage chemotherapy).
• Women who are pre-menopausal must have a negative pregnancy test
• Subjects must agree to use appropriate contraception until 4 weeks after the completion of chemotherapy.
• Patients must be HIV negative.
• If patients have a history of malignancy other than cutaneous basal cell or squamous cell carcinoma, they must be disease-free for ≥ 5 years at the time of enrollment.
• Patients or their guardians must be capable of providing informed consent.

Exclusion Criteria:

• Patients with either parenchymal brain or lepto-meningeal involvement.
• 7 or more consecutive days of prednisone therapy prior to therapy.
• Known pregnancy or breast-feeding.
• Medical illness unrelated to HL, which in the opinion of the attending physician and principal investigator will preclude administration of chemotherapy safely. This includes patients with uncontrolled infection, chronic renal insufficiency, myocardial infarction within the past 6 months, unstable angina, cardiac arrhythmias other than chronic atrial fibrillation and chronic active or persistent hepatitis
• History of any malignancy for which the disease-free interval is <5 years, excluding curatively treated cutaneous basal cell or squamous cell carcinoma and carcinoma in-situ of the cervix.