HomeResearchIntramural ResearchResearch Investigators Milgram Lab

Print Version

Sharon L. Milgram, Ph.D. Adjunct Investigator National Human Genome Research Institute Senior Investigator National Heart, Lung, and Blood Institute B.S. Temple University, 1984 Ph.D. Emory University, 1991 (301) 594-2053 (301) 402-0483 milgrams@od.nih.gov Building 2, Room 2E04 2 Center Dr, MSC 0240 Bethesda, MD 20892-0240 Selected Publications

Dr. Milgram studies cell signaling and protein trafficking in polarized cells, including kidney and airway epithelial cells. Epithelial cells form a lining at the surface of the skin and along membranes within the body. This lining is essential for cell defense, nutrient absorption and ion transport. Her research group investigates how the topmost (or apical) membrane receptors regulate the activity of ion channels, including the epithelial sodium channel (ENaC) and the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel.

Focused initially on the airway epithelium, Dr. Milgram's research program has now expanded to study other epithelial cells and model systems, including the kidney and gastrointestinal tract. Her laboratory's findings suggest that receptors, signaling intermediates and effectors are compartmentalized into regulatory complexes that increase the fidelity and efficiency of cell signaling. These studies utilize diverse approaches, ranging from in vitro biochemical assays to physiological assays in knock-out mice.

Top of page

Last Reviewed: June 30, 2008